腹膜透析患者饮食成分与大动脉僵硬度的关系  

Association between diet and arterial stiffness in patients with continuous ambulatory peritoneal dialysis

作　　者：张聪[1] 邵凤民[2] 鲁新红[3] 田顺利[3] 范晓红[3] 

机构地区：[1]郑州大学第一附属医院肾内科,450052 [2]河南省人民医院肾内科 [3]北京大学第三医院肾内科

出　　处：《中国实用医刊》2010年第9期17-19,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨持续性非卧床腹膜透析(CAPD)患者饮食营养成分与大动脉僵硬度的关系.方法 选取同一中心92例饮食状况稳定的CAPD患者为研究对象.采用自动脉搏波速度分析仪测定脉搏波速度(PWV),由专业的营养师计算患者饮食组成部分,与PWV进行相关和多元回归分析,筛选出大动脉僵硬度的影响因素.结果 Pearson分析发现PWV与尼克酸 (r=-0.148,P<0.05)、维生素C(r=-0.125,P<0.05)、维生素E(r=-0.181,P<0.05)、碳水化合物(r=-0.181,P<0.05)、能量(r=-0.147,P<0.05)、蛋白质(r=-0.154,P<0.05)相关.多元回归分析结果显示,饮食中维生素E(β=-0.163,P=0.022)及碳水化合物(β=-0.284,P=0.025)是PWV的独立相关因素,二者一起决定了PWV变化的5%.结论 腹膜透析患者饮食维生素E、碳水化合物与PWV密切相关.维生素E、碳水化合物是腹膜透析患者大动脉僵硬度的独立影响因素.Objective To investigate the association between dietary nutritive composition and pulse wave velocity (PWV)in patients with continuous ambulatory peritoneal dialysis (CAPD). Methods CAPD patients (n=92) of stable dietary habits in one single center were included.Carotid-femoral PWV was measured with a validated automatic device and was used as an index of large arterial stiffness.Dietary nutritive composition of these patients were calculated by a professional nutritionist. Pearson's correlation and multiple regression analysis were performed to identify the relationship between nutritive composition and PWV.Results PWV was closely associated with nicotinic acid (r=-0.148,P<0.05),vitamin C(r=-0.125,P<0.05),vitamin E (r=-0.181,P<0.05),carbohydrates (r=-0.181,P<0.05),energy (r=-0.147,P<0.05),protein(r=-0.154,P<0.05), respectively.Multiple regression analysis showed that PWV was independently determined by vitamin E (β=-0.163,P=0.022)and Carbohydrates (β=-0.284,P=0.025).They accounted for 5% of the total variance.Conclusions Dietary vitamin E and carbohydrates is closely associated with PWV in CAPD patients.Dietary vitamin E and carbohydrates are independent influential factors for PWV in CAPD patients.Suggesting that the relationship may help to explain the possible protective effect of vitamin E and carbohydrates on cardiovascular risk and mortality through alleviating atherosclerosis in CAPD patients.

关 键 词：心血管疾病 动脉硬化 维生素 脉搏波速度 碳水化合物 

分 类 号：R54[医药卫生—心血管疾病]