非小细胞肺癌中p-STAT3与Ki67的表达及意义  

The expression and significance of phosphorylated signal transducer and activator of transcription 3 and Ki67 in non-small cell lung cancer

作　　者：刘培杰[1] 

机构地区：[1]郑州大学第五附属医院呼吸内科,450052

出　　处：《中国实用医刊》2010年第11期22-24,共3页Chinese Journal of Practical Medicine

摘　　要：目的 研究磷酸化信号转导与转录活化因子3(p-STAT3)和 Ki67在非小细胞肺癌(NSCLC)发生、发展中的作用及相互关系.方法 采用免疫组织化学S-P法检测67例非小细胞肺癌组织和41例正常肺组织中p-STAT3与Ki67的表达.结果 非小细胞肺癌组织中p-STAT3的阳性表达率(67.16%,45/67)显著高于正常肺组织(17.07%,7/41),Ki67在非小细胞肺癌组织中的表达(76.12%,51/67)高于正常肺组织(7.31%,3/41).p-STAT3和 Ki67的表达与临床分期、有无淋巴转移和分化程度相关(P均<0.05),与患者年龄、性别、肿瘤位置及大小无关.p-STAT3的表达与Ki67表达呈正相关.结论 p-STAT3的异常活化可促进恶性肿瘤细胞的过度增殖,Ki67较好的反应了肺癌细胞的增殖状态.二者结合检测对非小细胞肺癌的临床诊断和治疗有一定价值.Objective To study the expressions of phosphorylated signal transducer and activator of transcription 3(p-STAT3)and Ki67 in non-small cell lung cancer and their significance in tumor development and progression. Methods The expression of p-STAT3 and Ki67 were detected in 67 lung carcinoma tissues and 41 normal lung tissues by immun histochemical method. Results The positive rate of p-STAT3 in non-small cell lung cancer (67.16%,45/67) was significantly higher than that in normal lung tissue(17.07%,7/41). The positive rate of Ki67 in non-small cell lung cancer (76.12%,51/67) was significantly higher than that in normal lung tissue(7.31%,3/41).The expression of p-STAT3 and Ki67 were associated with clinical stages, lymph node transferation and histological grades(P<0.05). The expression of p-STAT3 and Ki67 were not associated with ages, sex, tumor location or size.The expression of p-STAT3 was positively correlated with Ki67 expression. Conclusions Abnormal activation of p-STAT3, can lead to excessive proliferation of tumor cells and Ki67 is a favorable indicator of proliferation of lung tumor cells, and the combined detection of p-STAT3 and Ki67 may be valuable for diagnosis and treatment of non-small cell lung cancer.

关 键 词：非小细胞肺癌 P-STAT3 KI67 阳性表达率 lung cancer tumor cells activator 正常肺组织 肺癌组织 diagnosis and treatment carcinoma tissues positive clinical stages 转录活化因子 免疫组织化学 恶性肿瘤细胞 significance development 诊断和治疗 detection 

分 类 号：R734.2[医药卫生—肿瘤]