A型肉毒毒素治疗特发性眼睑痉挛及Meige综合征的临床观察  

Clinical observation of botulinum toxin type A fortreatment of blepharospasm and Meige syndrome

作　　者：黄月[1] 张杰文[1] 成巧梅[1] 叶松岩[1] 赵宁[1] 

机构地区：[1]河南省人民医院神经内科,郑州450003

出　　处：《中国实用医刊》2010年第12期24-25,共2页Chinese Journal of Practical Medicine

摘　　要：目的 探讨A型肉毒毒素治疗特发性眼睑痉挛及Meige综合征的疗效.方法 采用A型肉毒毒素局部多点注射治疗特发性眼睑痉挛及Meige综合征32例,对治疗前后的病情随访并进行分级比较.结果 症状完全缓解20例,占62.5%,明显缓解11例,占34.4%,部分缓解1例,占3.1%,疗效平均持续约3～6个月,复发者重复注射仍有效且剂量无增加,局部不良反应轻微、短暂.结论 局部注射A型肉毒毒素治疗特发性眼睑痉挛及Meige综合征是一种安全有效且简便易行的方法,可重复注射.OObjective To explore the efficacy of botulinum toxin type A (BOTOX-A) for treatment of blepharospasm and Meige syndrome. Methods Local multi-point injection of BOTOX-A was performed for 32 patients of blepharospasm and Meige syndrome. The efficacy and side effects were compared between the results before and after injection. Results Symptoms of 62.5% of the patients were completely relieved,34.4% were obviously relieved,3.1% were partially relieved. The average of therapeutic efficacy lasted 3 to 6 monthes.It was effective to the recurrent patients repeated with injection.Local untoward effect was light and transient. Conclusions Local injection of BOTOX-A is a simple,effective and safe therapy for blepharospasm and Meige syndrome.

关 键 词：型肉毒毒素 注射治疗 特发性眼睑痉挛 综合 临床观察 type A effective 重复注射 BOTULINUM TOXIN Results 局部注射 side effects treatment 完全缓解 平均持续 疗效 方法 不良反应 安全有效 simple 

分 类 号：R77[医药卫生—眼科] R74[医药卫生—临床医学]