Smac和XIAP基因在肾细胞癌中的表达及意义  

Expression and clinical significance of Smac and XIAP in renal cell carcinoma

作　　者：王智勇[1] 张雪培[1] 魏金星[1] 赵钢勇[1] 

机构地区：[1]郑州大学第一附属医院泌尿外科,450052

出　　处：《中国实用医刊》2010年第17期4-5,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨Smac和XIAP基因在肾细胞癌组织中的表达及其临床意义.方法 采用免疫组织化学法检测95例肾癌标本不同分型、分级、分期及10例正常肾组织中Smac和XIAP的表达,分析其表达与肾癌分级、分期的关系及二者表达相关性.结果 Smac在各型肾细胞癌中随分期、分级的增加表达减低,XIAP在各型肾细胞癌中随分期、分级的增加表达增高,二者的表达呈负相关.结论 Smac和XIAP表达与肾细胞癌分期、分级关系密切,共同参与了肾癌的发生发展。Objective To study the expression and significance of Smac and XIAP in renal cell carcinoma(RCC). Methods The expressions of Smac and XIAP were detected using SP immunohistochemical technique in 95 cases of RCC and 10 cases of normal renal tissue. Results The postitive expressions of Smac were statistically significant differences in different clinical statges. The postitive expressions of XIAP were higher in RCC related to the lower histological grade. Smac protein and XIAP protein expression had negative correlation. Conclusions It indicate that Smac and XIAP may play an important role in RCC. The expression of Smac and XIAP are statistically significant associated with tumor grade and clinical stage.

关 键 词：SMAC XIAP基因 肾细胞癌分期 表达相关性 renal cell carcinoma SIGNIFICANT 分级关系 protein expression 免疫组织化学法 肾癌 significance RCC differences different 临床意义 共同参与 发生发展 表达增高 XIAP表达 negative 

分 类 号：R737.11[医药卫生—肿瘤]