p33ING1b蛋白在胆囊癌中表达的研究  

EXPRESSION OF p33ING1b IN GALLBLADDER CARCINOMA

作　　者：龚伟[1,2] 张生来[2] 杨勇[2] 王雪峰[2] 储冰峰[2] 方国恩[1] 毕建威[1] 全志伟[2] 刘颖斌[2] 张勇[2] 

机构地区：[1]上海第二军医大学研究生院,上海200092 [2]上海交通大学医学院附属新华医院普外科

出　　处：《肝胆外科杂志》2011年第1期61-63,共3页Journal of Hepatobiliary Surgery

基　　金：上海市科委自然基金(张勇;09ZR1419800);上海市科委国际合作项目(龚伟;10410700100);上海市卫生局课题(龚伟;2009064)

摘　　要：目的探讨抑癌基因p33ING1b在胆囊癌组织中的表达情况并探讨其临床意义。方法采用P免疫组化法测定p33ING1b蛋白在20例慢性胆囊炎及30例胆囊癌石蜡标本的阳性表达率及其与临床分级分期的相关性。结果 p33ING1b在胆囊癌中的表达率为53.33%(16/30)明显低于胆囊炎的100%(20/20),差异有显著意义(P<0.05)。胆囊癌中低分化组(25%)的表达明显低于高(76.92%)、中分化组(55.56%)。结论 p33ING1b在胆囊恶性肿瘤组织中呈低表达,其表达程度随着分化级别的降低而减少,表明胆囊恶性肿瘤中存在p33ING1b功能的缺失。Objective To study the expression of inhibitor of growth 1 (p33ING1b) in gallbladder carcinomas and its clinical significance.Methods The expression of p33ING1b in 33 cases of gallbladder carcinomas and 20 cases of chronic cholecystitis was observed by immunohistochemical analysis. Results In all cases of chronic cholecystitis, the expression of p33ING1b is 100% (20/20),while the expression of p33ING1b is of 53.33%(16/30)in gallbladder carcinoma,There is significant difference of p33ING1b between the chroni...

关 键 词：抑癌基因 胆囊癌 ING1B 

分 类 号：R735.8[医药卫生—肿瘤]