盐酸氨溴索咀嚼片的制备及质量控制  

Preparation and quality control of ambroxol hydrochloride chewing tablets

作　　者：陈亮[1] 符旭东[2] 刘祖雄[2] 郑汉平[2] 王志朝[2] 

机构地区：[1]解放军第161医院药剂科,湖北武汉430010 [2]解放军广州军区武汉总医院药剂科,湖北武汉430070

出　　处：《临床军医杂志》2010年第5期834-836,共3页Clinical Journal of Medical Officers

摘　　要：目的 介绍盐酸氨溴索咀嚼片的制备及质量控制方法.方法 盐酸氨溴索咀嚼片的溶出度测定采用紫外分光光度法,其含量测定则采用高效液相色谱法.结果 盐酸氨溴索咀嚼片的含量测定的线性范围为15～45 mg/L.结论 本制剂处方工艺成熟,检测方法简便、准确、可靠,适用于医院制剂室配制和应用.Objective To study preparation technology of ambroxol hydrochloride chewing tablets,and to establish its quality contro1.Methods UV spectrophotography was used to determine the dissolution of ambroxol hydroehloride chewing tablets,and HPLC was used to determine content of ambroxol hydroehloride.Results The detected concentration of ambroxol hydrochloride was linear at 15-45 μg/mL.Conclusion The preparation technology of ambroxol hydrochloride is reliable.The measuring methods can be used in hospital production,for they are simple,accurate and reliable.

关 键 词：盐酸氨溴索 咀嚼片 制备 质量控制方法 含量测定 紫外分光光度法 高效液相色谱法 医院制剂室 溶出度测定 制剂处方 线性范围 检测方法 工艺成熟 结果 

分 类 号：R82[医药卫生—临床医学]