DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with β-sitosterol:In vitro antimicrobial activity  

作　　者：Nida N.Farshori Mudasir R.Banday Zeeshan Zahoor Abdul Rauf 

机构地区：[1]Department of Chemistry,Aligarh Muslim University,Aligarh 202002,India [2]Department of Biochemistry,Aligarh Muslim University,Aligarh 202002,India

出　　处：《Chinese Chemical Letters》2010年第6期646-650,共5页中国化学快报（英文版）

摘　　要：A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral data.All the synthesized compounds were evaluated for their in vitro antimicrobial activity.The minimum inhibitory concentration(MIC),minimum bacterial concentration(MBC) and minimum fungicidal concentration(MFC) were determined for test compounds as well as for reference standards.Among the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities.A new series of fatty alkenoates were synthesized using an appropriate synthetic route involving DCC and DMAP as catalysts. Compounds were characterized by their spectral data.All the synthesized compounds were evaluated for their in vitro antimicrobial activity.The minimum inhibitory concentration(MIC),minimum bacterial concentration(MBC) and minimum fungicidal concentration(MFC) were determined for test compounds as well as for reference standards.Among the compounds tested, compounds having hydroxy group at the fatty acid chain showed the most potent antibacterial as well as antifungal activities.

关 键 词：Fatty acids Β-SITOSTEROL DCC DMAP IR NMR Mass Antimicrobial activity 

分 类 号：O621.2[理学—有机化学]