微波辅助合成N-苯氧乙基苯磺酰胺类衍生物  

Microwave assisted synthesis of N-phenoxyethyl benzene-sulfonamide derivatives

作　　者：谢蒋平[1] 曾红[2] 何菱[1] 

机构地区：[1]四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都610041 [2]四川大学华西口腔医院,四川成都61004

出　　处：《华西药学杂志》2010年第6期655-657,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的用微波反应合成了一系列N-苯氧乙基苯磺酰胺类衍生物。方法以N,N-二甲基甲酰胺(DMF)做溶剂,在K2CO3和溴化三乙基苄基铵(TEBA)相转移催化剂存在的情况下,利用微波辐射辅助合成N-苯氧乙基苯磺酰胺类衍生物。结果合成了12个N-苯氧乙基苯磺酰胺类衍生物,并经1HNMR确证结构。结论与传统的加热方法比较,微波缩短了反应时间,提高了合成产率。OBJECTIVE To synthesize a series of N-phenoxyethyl benzene sulfonamide derivatives with microwave irradiation.METHODS N-phenoxyethyl benzene sulfonamide derivatives were synthesized using K2CO3 as base and TEBA as phase-transfer catalyst in DMF under microwave irradiation.RESULTS Twelve kinds of N-phenoxyethyl benzene sulfonamide derivatives were synthesized,their structures were identified by 1 HNMR.CONCLUSION Compared with the traditional heating method,the microwave irradiation assisted method can simpli...

关 键 词：微波辅助合成 N-苯磺酰胺类衍生物 相转移催化 

分 类 号：R914[医药卫生—药物化学]