IGF-Ⅰ和IGF-Ⅱ在人结直肠腺瘤和结直肠癌中的表达及意义  

The expression of IGF-Ⅰ and IGF-Ⅱ in human colorectal adenoma and colorectal cancer and its significance

作　　者：文国容[1] 庹必光[1] 刘华庆[2] 李娟[1] 王雪[1] 刘雪梅[1] 于之昊[1] 

机构地区：[1]贵州省遵义医学院附属医院消化内科,563000 [2]遵义医学院附属医院病理科

出　　处：《贵州医药》2010年第12期1069-1071,共3页Guizhou Medical Journal

摘　　要：目的探讨IGF-Ⅰ和IGF-Ⅱ与结直肠腺瘤及结直肠癌发生、发展的关系。方法用免疫组化法检测IGF-Ⅰ和IGF-Ⅱ在人结直肠腺瘤和结直肠癌中的表达,用IPWIN60软件测量染色情况,计算平均光密度。结果 IGF-Ⅰ、IGF-Ⅱ在正常肠粘膜中少量表达,在结直肠管状腺瘤和绒毛状腺瘤中表达明显增强,结直肠癌中则高表达。与正常肠粘膜组比较,结直肠管状腺瘤组、绒毛状腺瘤组、结直肠癌组的表达均有显著差异(P<0.01);与结直肠管状腺瘤组和绒毛状腺瘤组比较,IGF-Ⅰ和IGF-Ⅱ在结直肠癌中的表达显著增强(P<0.01)。结论 IGF-Ⅰ和IGF-Ⅱ在正常结直肠粘膜、管状腺瘤、绒毛状腺瘤、结直肠癌中的表达依次增加,IGF-Ⅰ和IGF-Ⅱ可能在结直肠腺瘤及结直肠癌的发生、发展中起一定作用。Objective To investigate the relationship of the insulin-like growth factor-Ⅰ(IGF-Ⅰ) and insulin-like growth factor-Ⅱ(IGF-Ⅱ) with differentiation of colorectal cancer and colorectal adenoma.Methods The expression of IGF-Ⅰand IGF-Ⅱ was detected by immunohistochemistry in human colorectal cancer and colorectal adenoma,measurement of staining,calculation of average optical density(OD) by IPWIN60.Results IGF-Ⅰand IGF-Ⅱwere less expressed in normal intestinal mucosa and were significantly increased in canalicular adenoma and villous adenoma and were higher level in colorectal cancer.In contrast with normal,existed significant differences for the IGF-Ⅰ and IGF-Ⅱ expressions in the canalicular adenoma,villous adenoma and colorectal cancer(P<0.01).Compared with canalicular adenoma and villous adenoma,the expressions of IGF-Ⅰ and IGF-Ⅱ was significant higher in colorectal cancer(P<0.05).Conclusion Positive expression rate of IGF-Ⅰ and IGF-Ⅱ enhanced in mucous membrane of colon and rectum,canalicular adenoma,villous adenoma and colorectal cancer.IGF-Ⅰ and IGF-Ⅱ may play pivotal roles in the progression of colorectal adenoma and colorectal cancer.

关 键 词：胰岛素样生长因子-Ⅰ 胰岛素样生长因子-Ⅱ 管状腺瘤 

分 类 号：R735.3[医药卫生—肿瘤]