老年晚期肿瘤患者下呼吸道感染病原菌分布及耐药性分析  

Distribution of clinical bacterial and analisis of drug susceptibility in lower respiratory tract infection among advanced tumor elder

作　　者：亓久德[1] 刘丽娟[1] 吕江峰[1] 

机构地区：[1]莱芜市人民医院,山东莱芜271100

出　　处：《医学检验与临床》2006年第3期61-63,共3页Medical Laboratory Science and Clinics

摘　　要：目的了解老年晚期肿瘤患者下呼吸道感染的病原菌分布及其耐药性分析。方法416例老年晚期肿瘤合并下呼吸道感染患者的痰及下呼吸道分泌物进行常规细菌培养鉴定,用NCCLS推荐的K-B法测定病原菌的耐药性。结果416例病原菌中革兰阴性杆菌240株占57.69%,以铜绿假单胞杆菌为主,构成比为25.72%(107株),依次为大肠埃希氏菌和肺炎克雷伯杆菌。革兰阴性杆菌最敏感的药物是碳青霉烯类药物亚胺培南,耐药率均在13%以下。革兰阳性球菌102株,构成比为24.52%,其中以金黄色葡萄球菌为主,构成比为18.03%(75株),MRSA占61.3%;在药物敏感试验方面除对万古霉素100%敏感外,对其他药物都表现出不同的耐药率(8.5%-100%)。真菌的检出率为17.79%(74株),以白色念珠菌为主,构成比为12.26%(51株)。结论老年晚期肿瘤病人下呼吸道感染致病危险因素多样,应及时送检病原标本做细菌培养,按药敏结果合理选用抗生素。Objective To investigate the distribution of clinical bacterial and analysis it'sdrugsusceptibility in lower respiratory tract infection among older advanced carcinoma patients.Methods The secretions and sputum of 416 cases were to conduct bacteria culturingand determinding.According to the standard of NCCLS.Their susceptibility to antibiotics were examed by KrbyBaner disc agar diffusion test.Results In all clinical bacteria The amount of Gram-negitive bacteria was 240(57.69%).Gram-positive bacterial 102(24.52%).Pseudomonas 107(25.72%).S.aureus 75(18.03%).The proportion of MRSA was 61.3%.The G'bacteria to imipenem was sensitive.It's resistant rate was under 13%.Drug sensitive rate of G^+ bacteria tovancomycin was 100%.It expressed different degree resistance to other drugs(8.5%-100%).The amount of fungi was 74(17.79%).Cadida albicans was 51(17.79%).Conclusions Lower respirtorytract infection among advanced tumor elder contribute to multiple factors.We should sentspecimens on time to culture and determind in order to reasonably apply antibacterials.

关 键 词：老年 晚期肿瘤患者 下呼吸道感染 病原菌分布 耐药性分析 respiratory tract infection 构成比 革兰阴性杆菌 药物敏感 细菌培养 下呼吸道分泌物 金黄色葡萄球菌 肺炎克雷伯杆菌 致病危险因素 晚期肿瘤病人 耐药率 革兰阳性球菌 大肠埃希氏菌 假单胞杆菌 白色念珠菌 

分 类 号：R730.4[医药卫生—肿瘤]