升主动脉缩窄鼠升主动脉瘤的扫描电镜观察  

Scanning electron microscope observation of rat ascending aortic aneurysms induced by ascending aorta banding

作　　者：范军[1] 柏树令[1] 朱小兵[1] 刘月华[2] 

机构地区：[1]中国医科大学基础医学院解剖学教研室,沈阳110001 [2]中国医科大学基础医学院组织学与胚胎学教研室,沈阳110001

出　　处：《解剖学杂志》2005年第4期410-412,共3页Chinese Journal of Anatomy

摘　　要：目的:观察升主动脉缩窄鼠升主动脉瘤的形态特征,为动脉瘤的临床和实验研究提供资料。方法:以幼年Wistar大鼠制作升主动脉缩窄鼠动脉瘤模型,取出动脉瘤,用扫描电镜观察。结果:动脉瘤的弹力板出现肥大、断裂,弹力板间的弹力纤维广泛破坏;动脉瘤壁中有炎性细胞浸润;平滑肌细胞大部分萎缩或消失;动脉瘤内皮严重受损,部分动脉瘤壁中有红细胞浸润。结论: 动脉瘤存在超微结构的改变,提示以上形态学改变是动脉瘤发生的重要病理学基础。To investigate the morphological features of ascending aortic aneurysms induced by ascending aorta banding, providing data for experimental and clinical research of aortic aneurysm. Methods： Aortic aneurysm rat model was induced by ascending aorta banding of young Wistar rats. The aortic aneurysms were removed and observed urider scanning electron microscope. Results： The elastic lamellas of aneurysms had hypertrophy and fragmentation; the walls of the ascending aorta aneurysms were infiltrated by the inflammatory cells; the elastic fibers among the elastic lamellas were widely destroyed; most of the smooth muscle cells were atrophied or vanished; the endothelia of the ascending aorta aneurysm were seriously destroyed; and the walls of some ascending aorta aneurysms were infiltrated by the erythrocytes. Conclusion： The ascending aorta aneurysm has ultrastructural changes, which is the important pathologic basis for the ascending aorta aneurysm.

关 键 词：升主动脉缩窄 小鼠 升主动脉瘤 扫描电镜 病理学 形态学 超微结构 

分 类 号：R543[医药卫生—心血管疾病]