极化液及纠正酸中毒对家兔高钾血症的治疗  

Polarized Solution Treatment and Sodium Bicarbonate on Hyperkalemia in Rabbits

作　　者：杨黎黎[1] 金会艳[1] 余志诚[1] 李树清[1] 

机构地区：[1]昆明医学院基础医学机能实验中心,云南昆明650500

出　　处：《昆明医学院学报》2011年第12期3-7,共5页Journal of Kunming Medical College

基　　金：国家自然科学基金资助项目(30971171)

摘　　要：目的探究一种稳定的高钾血症造模方法比较,极化液治疗及NaHCO3治疗对家兔实验性高钾血症的疗效并探讨其可能机制.方法将30例家兔随机平均分成3组,运用"深静脉滴注法"造模成功后,分别进行生理盐水治疗,极化液治疗和碳酸氢钠治疗.结果 30例家兔通过颈外静脉滴注3%的氯化钾后均出现了典型的心电图变化,并且血清钾显著升高(P<0.01);分组治疗后,静脉滴注极化液和4%碳酸氢钠均可使心电图基本恢复正常血钾浓度明显下降(P<0.05).结论深静脉滴注法是一种稳定可靠,易于操作的高钾血症模型复制方法,极化液和碳酸氢钠对高钾血症有抢救治疗作用.Objective To investigate a steady way which named'intravenously guttae'of preparation of hyperkalemia in rabbit,and compare two different treatment methods polarized solution treatment and sodium bicarbonate treatment.Methods 30 rabbits were randomly divided into 3 groups:Saline group,polarized solution(glucose-insulin)group and sodium bicarbonate group(n=10 in each group).All rabbits were injected with 3% KCl and were treated with different ways.Results Typical ECG changes were found,and serum levels of were increased(P<0.05)in all 30 rabbits in three groups after injection of 3% KCL.After treatment,compared with Saline group,serum levels of were decreased significantly(P<0.05)and ECG recovered to normal in glucose-insulin group and sodium bicarbonate group.Conclusion 'Intravenously guttae'is a simple and steady way of preparation of hyperkalemia model.Glucose-insulin and sodium bicarbonate are effective methods for the treatment of hyperkalemia.

关 键 词：高钾血症 动物模型 家兔 极化液 碳酸氢钠 

分 类 号：R-33[医药卫生]