High expression of RbAp46 gene in patients with acute leukemia or chronic myelogenous leukemia in blast crisis  

作　　者：HU Shao-yan CHEN Zi-xing GU Wei-ying CEN Jian-nong ZHAO Ye 

机构地区：[1]Jiangsu Institute of Hematology, First Affiliated Hospital, Suzhou University, Suzhou 215006, China [2]Department of Hematology, First Affiliated Hospital, Hebei North University, Zhangjiakou 075029, China [3]Department of Hematology, First Hospital of Changzhou, Changzhou 213003, China

出　　处：《Chinese Medical Journal》2005年第15期1295-1298,共4页中华医学杂志（英文版）

基　　金：ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina(No.39770306).

摘　　要：The retinoblastoma （Rb） suppressor associated protein 46 （ RbAp46 ） also named retinoblastoma binding protein 7 （RBBP7） was first identified as a protein in HeLa cells that binds to an Rb affinity column. RbAp46 has been shown to be a core component of the mSin3 histone deacetylase （HDAC） complex and NuRD （ a multi-subunit complex containing chromosome-remodeling activity）. 2 RbAp46 is also known as the histone acetyltransferase （HAT） type B subunitThe retinoblastoma （Rb） suppressor associated protein 46 （ RbAp46 ） also named retinoblastoma binding protein 7 （RBBP7） was first identified as a protein in HeLa cells that binds to an Rb affinity column. RbAp46 has been shown to be a core component of the mSin3 histone deacetylase （HDAC） complex and NuRD （ a multi-subunit complex containing chromosome-remodeling activity）. 2 RbAp46 is also known as the histone acetyltransferase （HAT） type B subunit

关 键 词：acute leukemia· chronic myelogenous leukemia · retinoblastoma binding protein 7·real-time polyrnerase chain reaction 

分 类 号：R733.7[医药卫生—肿瘤]