肿瘤研究的金钥匙:肿瘤干细胞  

Golden Key of Cancer Study: Cancer Stem Cells

作　　者：曹曙[1] 何志颖[1] 阎龙[1] 胡以平[1] 

机构地区：[1]第二军医大学细胞生物学教研室,上海200433

出　　处：《生物技术通讯》2005年第4期423-425,共3页Letters in Biotechnology

基　　金：国家自然科学基金项目(30270603);上海市科委重大项目(03DJ14020)

摘　　要：“肿瘤干细胞学说”认为肿瘤组织不是均一的,其中只有一小部分肿瘤干细胞具有诱发并维持肿瘤恶性表达的能力。这一概念的提出为肿瘤真正意义上的靶向治疗找到了良方妙药,即选择性杀伤肿瘤干细胞从而治愈肿瘤。找到肿瘤干细胞并了解其生物学特性对我们真正理解肿瘤的发生、发展和转归机制,根治肿瘤并防止肿瘤的转移和复发具有积极意义。本文概述对人淋巴细胞白血病、乳腺肿瘤、脑部肿瘤及其他肿瘤的肿瘤干细胞及其相关机制的研究进展。The theory, “Cancer Stem Cells”, considers that it is not homogeneous of the cancer tissue, in which only a small part of cancer stem cells possess the potency to induce and maintain the malignant expression of cancer. The posing of this conception offers a marvelous way to the target therapy to cancer in the true meaning. It means that we can selectively kill the cancer stem cells to cure the cancer. The separation of the stem cells from the cancer tissue and the comprehension of its biological character have positive significance to understand the cancer＇s mechanism of genesis, development and transformation, to cure the cancer radically and to prevent the cancer from transferring and relapsing. In this paper, the research and some relative mechanism of the cancer stem cells of human lymphoblastic leukemia, breast cancer, brain tumor and other cancers were discussed.

关 键 词：肿瘤干细胞 人淋巴细胞白血病 乳腺肿瘤 脑肿瘤 肝肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]