血清性激素的水平对男性肺癌患者诊断的意义  

The significance of serum sexual hormones’ level in male patients with lung cancer

作　　者：陈名声[1] 徐焰[1] 郝晓柯[1] 张永生[1] 徐威[1] 卢宝弼[1] 

机构地区：[1]第四军医大学西京医院内分泌室,西安710032

出　　处：《中国肺癌杂志》2005年第4期300-303,共4页Chinese Journal of Lung Cancer

摘　　要：背景与目的研究表明内分泌激素失调在肿瘤的发生发展过程中有重要的作用。本研究拟探讨检测男性肺癌患者血清性激素水平的临床意义。方法采用放射免疫法和免疫放射法测定男性肺癌患者(62例)、肺良性疾病患者(30例)及正常健康人(30例)血清雌二醇(E2)、睾酮(T)、泌乳素(PRL)、生长激素(GH)、黄体生成素(LH)、卵泡刺激素(FSH)、促甲状腺激素(TSH)水平。结果男性肺癌组与正常对照组比较T水平显著降低(t=0.348,P<0.01),E2、PRL、FSH水平显著升高(t=0.362,P<0.01;t=2.913,P<0.05;t=2.739,P<0.01);男性肺癌组与肺良性疾病组比较T水平显著降低(t=3.903,P<0.05);鳞癌组和腺癌组与小细胞肺癌组比较T水平显著降低(t=0.358,P<0.01;t=3.902,P<0.05),鳞癌组与腺癌组比较FSH及TSH显著升高(t=3.918,P<0.01;t=2.912,P<0.05)。有淋巴结转移组与无淋巴结转移组比较T水平显著降低(t=3.914,P<0.01),其它激素无明显差异。结论肺癌患者血清中性激素水平紊乱,检测血清中E2、T、PRL及FSH对肺癌的诊断有一定的价值,并可作为判断患者病情的指标。Background and objective Many researches indicate that endocrine imbalance plays an important role in the oncogenesis and development of malignant tumor. The aim of this study is to investigate the clinical significance of serum sexual hormones＇level in male patients with lung cancer. Methods RIA and IRMA were used to detect the levels of serum estrodiol （E2）, testosterone （T）, prolactin （PRL）, growth hormone （ GH）, luteinizing hormone （ LH）, follicle-stimulating hormone （FSH） and thyroid-stimulating hormone （TSH） in 62 lung cancer patients, 30 benign pulmonary disease patients and 30 healthy men. Results The level of T in male patients with lung cancer was obviously lower than that in healthy men （t= 0. 348, P〈 0.01） ; the levels of E2, PRL and FSH remarkably increased in male patients with lung cancer compared with healthy men （t=0.362, P〈0.01; t=2.913, P〈0.05, t=2.739, P〈0.01）; the level of T in male patients with lung cancer was obviously lower than that in patients with benign pulmonary diseases （t = 3. 903, P〈0.05）; the levels of T in squamous cell carcinoma group and adenocarcinoma group decreased significantly compared with small cell lung cancer group （t=0.358, P〈0.01; t=3.902, P〈0.05）. The levels of FSH and TSH in squamous cell carcinoma group were significantly higher than those in adenocarcinoma group （t= 3. 918, P〈0.01; t=2. 912, P〈0.05）. The level of T in lymph node metastasis group decreased obviously compared with non-lymph node metastasis group （t=3. 914, P〈0.01）, but the other hormones were at the same level in different pathological types of lung cancer. Conclusion There are some disturbance of serum sexual hormones＇ level in lung cancer patients. The detection of serum E2, T, PRL and FSH may have some value to lung cancer diagnosis and can be an index to predict the state of lung cancer.

关 键 词：肺肿瘤 性激素 诊断 

分 类 号：R734.2[医药卫生—肿瘤]