MMP-2、MMP-9、Cathepsin-D在淋巴结阴性乳腺癌中的表达及其与预后的关系  

Prognostic significance of MMP-2、MMP-9、Cathepsin-D expression in lymph node-negative breast carcinoma

作　　者：曹道成[1] 刘毅[1] 后强[1] 张俊坤[1] 崔杰[1] 李鹤成[2] 邵志敏[2] 

机构地区：[1]安徽省马鞍山市马钢医院外科,243000 [2]复旦大学附属肿瘤医院乳腺外科

出　　处：《中华普通外科杂志》2005年第8期510-512,共3页Chinese Journal of General Surgery

摘　　要：目的研究MMP-2、MMP-9(matrixmetalloproteinase,基质金属蛋白酶)、Cathepsin-D(组织蛋白酶D)在淋巴结阴性乳腺癌中的表达与预后的关系。方法用免疫组织化学ABC法检测270例淋巴结阴性乳腺癌患者肿瘤组织中MMP-2、MMP-9、Cathepsin-D的表达。结果肿瘤组织中MMP-2、MMP-9、Cathepsin-D的阳性率分别为56·7%(153/270)、59·6%(161/270)、55·6%(150/270);单因素分析MMP-2阳性、MMP-9阳性及两者共表达患者有较低的无复发生存率,多因素分析发现MMP-2和MMP-9共表达能独立预测患者的无复发生存率(RR=2·487;P<0·05)。结论在淋巴结阴性乳腺癌患者中MMP-2和MMP-9的阳性表达患者的预后较差。Objective To evaluate the prognostic significance of MMP-2 , MMP-9 and Cathepsin- D expression in lymph node-negative human breast carcinoma. Methods Specimens from the primary breast tumors of 270 axillary lymph node negative breast cancer patients were studied for MMP-2 , MMP-9 and Cathepsin-D protein expression by immunohistochemical staining. Results The positive expression of MMP-2, MMP-9 and Cathepsin-D was 56.7% （ 153/270 ）, 59. 6% （ 161/270 ） and 55.6% （ 150/270 ） , respectively. In univariate analysis, MMP-2, MMP-9 and the co-expression of MMP-2 and MMP-9 were significantly associated with tumor free survival. In multivariate analysis, co-expression of MMP-2 and MMP- 9 was unfavorablely related with tumor free survival （ RR = 2. 487 ; P 〈 0. 05 ）. Conclusion MMP-2 and MMP-9 are unfavorable prognostic factors in node-negative breast cancer patients.

关 键 词：淋巴结阴性乳腺癌 基因表达 疾病预后 基质金属蛋白酶-2 基质金属蛋白酶-9 组织蛋白酶D 

分 类 号：R737.9[医药卫生—肿瘤]