P53和CD44_(V6)蛋白在膀胱移行细胞癌的表达及其临床意义  

EXPRESSION OF P53 AND CD44__(V6) PROTEINS IN TRANSITIONAL CELL CARCINOMA OF THE BLADDER AND ITS CLINICAL SIGNIFICANCE

作　　者：李慎谦[1] 申永璋[2] 王甡[1] 王鹏举[1] 

机构地区：[1]青岛大学医学院第二附属医院泌尿外科,山东青岛266042 [2]日照市人民医院泌尿外科

出　　处：《齐鲁医学杂志》2005年第2期132-134,共3页Medical Journal of Qilu

摘　　要：①目的探讨P53与CD44v6蛋白在膀胱移行细胞癌的表达及其与膀胱移行细胞癌生物学行为的关系及临床意义.②方法采用免疫组化(SABC)方法检测64例膀胱移行细胞癌中P53、CD44v6蛋白的表达情况.③结果P53和CD44v6蛋白表达水平与膀胱移行细胞癌组织学分级、临床分期及复发密切相关(x2=6.24～17.34,P<.01);P53与CD44v6蛋白的表达呈正相关(r=0.28,P<.05).④结论P53和CD44v6检测可为判断膀胱移行细胞癌的恶性程度和复发提供参考依据.Objective To investigate the expression of P53 and CD44v6 proteins in transitional cell careinoma（TCC） of bladders and its relationship with the biological behavior of the disease. Methods The expression of P53 and CD44v6 proteins was detected immunohistochemically in 64 cases of TCC in bladder. Results The expression level of P53 and CD44v6 was closely related with the histological grading, clinical staging, and recurrence of the disease（χ^2= 6.24-17.34, P〈0. 01 ）. The expression of P53 was positively correlated with that of CD44v6（r=0. 28,P〈0.05）. Conclusion The detection of P53 and CD44v6 may be used to judge the malignancy and recurrence of the cancer.

关 键 词：膀胱肿瘤 蛋白质P53 蛋白质CD44v6 免疫组织化学 CD44V6蛋白 膀胱移行细胞癌 临床意义 P53 癌生物学行为 蛋白表达水平 

分 类 号：R735.2[医药卫生—肿瘤] R737.14[医药卫生—临床医学]