柑橘类黄酮诺必擂停的抗肿瘤作用及其机制  

Anticancer Activity and Mechanism of Action of Nobiletin,a Citrus Polymethoxy Flavonoid

作　　者：成美英[1] 张洪泉[1] 

机构地区：[1]扬州大学医药研究所,江苏扬州225001

出　　处：《药学进展》2005年第8期355-359,共5页Progress in Pharmaceutical Sciences

摘　　要：综述柑橘类黄酮诺必擂停(NOB)的抗肿瘤药理作用及其机制。NOB是从柑橘类果实中提取的一种具有抗癌作用的生物活性成分,能通过多重机制有效抑制多种肿瘤细胞的增殖,但对正常人体细胞增殖的影响小,且与其他抗癌药有协同作用,可逆转肿瘤的多药耐药性,有望成为一种新型肿瘤防治药物。The anticancer activity flavoniod, were reviewed. NOB, an and mechanism of action of nobiletin （NOB）, a active constituent extracted from Citrus reticulata Citrus polymethoxy Blanco, can inhibit proliferation of many tumors in multiple mechanisms, but it affects normal human cells a little. Besides it has synergism with other anticancer drugs and reverses multidrug resistance of tumor. It could be of future therapeutic value.

关 键 词：诺必擂停 抗肿瘤 药理作用 作用机制 协同作用 多药耐药性 

分 类 号：R730.5[医药卫生—肿瘤]