烟酸抗高脂血症鹌鹑氧自由基和脂质过氧化作用  

Anti-oxygen free radicals and anti-lipoperoxidation of nicotinic acid on hyperlipodemia quail

作　　者：杨旭辉[1] 马建慧[1] 朱敏恒[1] 李丽燕[1] 吴越[1] 

机构地区：[1]石河子大学药物研究中心,新疆石河子832002

出　　处：《中国药理学通报》2005年第8期993-995,共3页Chinese Pharmacological Bulletin

摘　　要：目的研究烟酸(Nicotinicacid,NA)对氧自由基的清除作用及抗脂质过氧化的作用。方法用食饵法诱导鹌鹑高脂模型,实验分空白对照组、高脂模型组、NA组(150mg·kg-1和75mg·kg-1)、维生素E组(100mg·kg-1),给药后每3wk抽1次血,连续3次,分别测定血浆及肝脏TC、TG、MDA、SOD。结果高脂饮食诱导3wk后动物血浆和肝脏TC、TG和MDA含量上升,SOD活力下降。NA用药3周后可降低血浆和肝脏中的TC、TG和MDA含量,提高SOD活力,且呈剂量依赖关系。结论NA对鹌鹑高脂血症模型具有抗氧自由基和脂质过氧化作用。Aim To study the oxygen free radical scavenging activities and antilipid peroxidation of nicotinic acid. Methods High lipid models of quail were induced by high fat diet. Five groups were divided, namely control group, high lipid group, NA group（ 150 mg·kg^-1and75 mg·kg^-1）, and Vit E group （100 mg· kg^-1）. The contents of TC,TG, MDA and activities of SOD were examined for 3 times in the plasma and liver after administering NA for 9 weeks. Results The results showed the increase of TC,TG and MDAcontents and decrease of SOD activities in high lipid groups by 3 weeks high fat diet. After administering NA for 3 weeks, NA reduced TC,TG and MDA contents and increased SOD activities, revealing the relationship to dose-dependence. Conclusion NA is most likely to possess the capabilities of anti-oxygen free radicals and anti-lipoperoxidation to hyperlipodemia quail.

关 键 词：烟酸 丙二醛 超氧化物歧化酶 

分 类 号：R-332[医药卫生] R589.205.3