润肠通便颗粒剂药效学研究  

Study on Pharmacodynamics of Run Chang Tong Bian Granules

作　　者：俞励平[1] 文洁[1] 孙素兰[1] 叶青山[1] 

机构地区：[1]中山大学药物开发中心,广州510080

出　　处：《中药材》2005年第8期685-688,共4页Journal of Chinese Medicinal Materials

摘　　要：目的研究润肠通便颗粒剂对小鼠及家兔胃肠蠕动功能的影响。方法采用小鼠胃排空、小鼠胃肠道及小肠推进运动、泻下作用等模型考察润肠通便颗粒剂的导泻作用;采用家兔离体回肠蠕动模型,观察润肠通便颗粒剂对肠道平滑肌功能的影响。结果润肠通便颗粒剂可明显提高炭末在小肠中的推进速度,对小鼠小肠推进有显著促进作用;可明显降低胃中甲基橙的残留率,对小鼠胃排空有显著促进作用;能明显减少小鼠排便时间和增加小鼠排便粒数;对家兔离体回肠平滑肌有兴奋作用,使其肌张力增高,节律存在,收缩幅度明显增加,但无强直收缩。结论润肠通便颗粒剂具有明显的润肠通便作用。Objeetive ：To study the effect of Run Chang Tong Bian Granules（RCTBG） on stomach and intestine peristalsis in mice and rabbits, Methods： We conducted the intestine peristalsis test and gastric emptying test to observe the purgative action of RCTBG and the eftect on isolated intestine of rabbits. Results： RCTBG could effectively expedite the advance speed of charcoal powder in the small intestine and improve the velocity of intestine. It could also reduce the residual rate of methyl orange in stomach and improve the velocity of gastrie emptying, RCTBG could remarkably shorten the time of defecation, increase excrement quantity of mice, excite the isolated intestine of rabbits and inerease its tension and contraction amplitude, Conclusion： RCTBG has remarkable effeet on catharsis.

关 键 词：润肠通便颗粒剂 便秘 离体回肠 润肠通便作用 颗粒剂 药效学研究 离体回肠平滑肌 胃肠蠕动功能 小肠推进运动 排便时间 

分 类 号：R151[医药卫生—营养与食品卫生学] R283.627[医药卫生—公共卫生与预防医学]