177例宫内产前诊断结果与分析  

Analysis of abnormal chromosome in 177 intrauterine prenatal diagnosis

作　　者：吴新华[1] 伍招娣[1] 邬玲仟[2] 龙志高[2] 张卫社[1] 谭金秀[1] 裴琛琳[1] 

机构地区：[1]中南大学湘雅医院妇产科,湖南长沙410008 [2]中国医学遗传学国家重点实验室,湖南长沙410078

出　　处：《中国现代医学杂志》2005年第16期2503-2505,共3页China Journal of Modern Medicine

摘　　要：目的分析胎儿染色体异常出现的频率及与前产诊断指征的关系。方法对有产前诊断指征的177名妊娠19￣32周的孕妇进行羊膜腔穿刺或脐静脉穿刺术,取羊水细胞或脐血细胞培养并分析胎儿染色体核型。结果177例产前诊断中,染色体异常23例,占12.99%(23/177)。其中高龄孕妇37例,染色体异常7例,异常染色体检出率为18.92%(7/37);孕妇本人或丈夫染色体携带者异常染色体检出率为33.33%(3/9);胎儿畸形的异常染色体检出率为15.63%(5/32)。结论在各类产前诊断指征中,出现胎儿染色体异常者依次以父或母为染色体结构异常携带者、高龄、B超检查异常者的频率高。[Objective] To study the frequency of the abnormal chromosome, and to investigate the relationship between the indications of prenatal diagnosis and abnormal karyotypes. [Methods] Cordoeentesis and amnioeentesis were performed in 177 pregnant women with the indications of prenatal diagnosis during 19-32 gestational weeks. The samples of fetal blood and amniotic fluid were analyed. [Results] 23 abnormal chrosome karyotypes were found in 177 examples and the abnormal rate of abnormal karyotypes was 12.99% （23/177）. 7 abnormal karyotypes were found in 37 advanced age pregnant woman and the abnormal rate was 18.93% （7/37）. The abnormal rate of pregnant woman or husband chromosome sickness that carried unusual chromosome and malformed fetuses were 33.33%（3/9） and 15.63% （5/32）, respectively. [Conclusions] In the pregnant women with prenatal diagnosis, abnormal karyotypes in fetuses are found to be higher in the following situations： pregnant woman or husband chromosome sickness, advanced maternal age, abnormal findings by ultrasound.

关 键 词：产前诊断 异常核型 染色体 

分 类 号：R714.15[医药卫生—妇产科学]