富勒烯-赖氨酸衍生物的合成及其体外抗癌活性研究  

Study on Synthesis and in vitro Antitumour Activity of Fullerene-lysine Derivative

作　　者：江贵长[1] 郑启新[1] 

机构地区：[1]华中科技大学生命学院

出　　处：《材料导报》2005年第8期135-138,共4页Materials Reports

基　　金：安徽省自然科学基金(No.2002kj290 and 2005kj141)

摘　　要：合成了一种新型纳米级富勒烯-赖氨酸衍生物,通过红外光谱、核磁共振、TEM 等分析手段对衍生物的组成和结构进行了表征,TEM 分析表明其在水溶液中的形貌为理想的球形,平均粒径约为30nm;研究了该衍生物的抗癌机理,体外抗癌活性测试结果表明,该衍生物对人体的骨癌等癌细胞均具有很好的抑制能力.其抑制能力与衍生物的浓度和光照强度有关。A novel fullerene-lysine derivative is synthesized by means of organic chemistry. It is soluble in polar solvents such as water, dimethyl sulfoxide and tetrahydrofuran et al. The product is characterized by FTIR, ^1 HNMR, TEM. TEM analysis shows that it presents an ideal spherical shape in water with an average particle diameter of about 30nm. The antitumour mechanism of the derivative is studied. The in vitro antitumour activity of the novel derivative is also tested and the result shows that the novel derivative exhibits better antitumour activity in vitro against bone tumour cells. The in vitro antitumour activity of the novel derivative is related to the derivative concentration, and the power of the light irradiation.

关 键 词：富勒烯-赖氨酸衍生物 水溶性 抗癌活性 纳米微球 

分 类 号：O631[理学—高分子化学]