儿茶儿茶素抑制流感病毒增殖作用的研究  

Study on Influenza Virus Inhibitory Effect of Catechu Extract

作　　者：郑群[1] 丁丽新[2] 石伟先[2] 赵文明[1] 

机构地区：[1]首都医科大学,100054 [2]北京市疾病预防控制中心

出　　处：《公共卫生与预防医学》2005年第4期12-14,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的研究儿茶儿茶素的抗流感病毒作用。方法应用鸡胚培养法和血凝抑制试验分析不同浓度的儿茶提取物对病毒增殖的影响。结果儿茶儿茶素最大无毒剂量为12.5 mg/ml,在3.12512.5 mg/ml浓度范围内对甲型和乙型流感病毒的增殖具有抑制作用,12.5 mg/ml能完全抑制病毒的增殖。结论提示该儿茶儿茶素具有抑制甲型和乙型流感病毒增殖的作用。Objective To study the anti-influenza effect of catechu extract. Methods The anti-viral effect of catechu extract was observed by the technique of chick-embryo culture. The hemagglutination inhibition test was used for analyzing the anti-viral effect of catechu extract. Results The results showed that the maximal non-toxic concentration of catechu extract was 12.5 mg/ml. It had significant inhibiting action on influenza A3 and B viruses with the dose between 3. 125 and 12.5 mg/ml. Conclusion The findings suggest that catechu extract has a strong anti-influenza effect on both type A and B influenza.

关 键 词：儿茶 甲型流感病毒 乙型流感病毒 鸡胚培养 

分 类 号：R373.13[医药卫生—病原生物学]