CD1a标记树突细胞在声门型喉鳞癌中的表达及其临床意义  

Expression and Clinical Significance of CD1a+ Dendritic Cells in Glottic Squamous Cell Carcinoma

作　　者：陈文宽[1] 陈福进[1] 曾宗渊[1] 伍国号[1] 郭朱明[1] 魏茂文[1] 杨安奎[1] 张诠[1] 何洁华[1] 候景辉[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2005年第9期1124-1126,共3页Chinese Journal of Cancer

摘　　要：背景与目的:树突细胞(dendriticcell,DC)是最重要的抗原呈递细胞(antigenpresentingcell,APC),而CD1a作为未成熟DC的标记物,在肿瘤的发生及发展过程中有一定的影响。本文旨在探讨CD1a+DC与声门型喉癌病理分级、T分期及局部复发的关系,从而间接了解它与预后的关系。方法:收集111例有完整病理资料及临床随诊资料的声门型喉鳞癌病例,并取17例非肿瘤组织做对照。用免疫组化技术检测CD1a+DC在癌组织中的表达,分析癌组织中CD1a+DC在不同病理分级、T分期及局部复发组织中的表达,间接了解其与声门型喉鳞癌预后的关系。结果:111例声门型喉鳞癌病例中,CD1a阳性率为59.46%(66/111);高分化组阳性率为71.43%(55/77),中低分化组阳性率为28.57%(11/34);T1+T2组阳性率为67.16%(45/67),T3+T4组阳性率为47.73%(21/44)。局部复发组阳性率为42.86%(12/28),局部无复发组阳性率为65.06%(54/83)。17例非肿瘤组织中CD1a均为阴性。结论:声门型喉鳞癌中,肿瘤细胞分化越差,T分期越高,则CD1a标记树突细胞阳性率越低。局部复发者CD1a+DC阳性率低。CD1a可作为预测声门型喉鳞癌预后的参考指标之一。BACKGROUND ＆ OBJECTIVE= Dendritic cells （DCs） are the most important antigen-presenting cells. CD1a, a marker of immature DCs, plays a role in tumorigenesis. This study was designed to explore the correlation of CDla^＋ DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma. METHODS： Clinical and followup data of 111 patients with glottic squamous cell carcinoma were analyzed retrospectively. The expression of CD1a^＋ DCs in the 111 specimens of glottic squamous cell carcinoma and 17 specimens of non-tumor tissue was detected by immunohistochemistry. Correlations of CD1a^＋ DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma were analyzed. RESULTS： Positive rates of CD1a^＋ DCs were 59.46% in glottic squamous cell carcinoma tissues, and 0 in non-tumor tissues; it was significantly higher in well-differentiated group than in moderately-and poorly-differentiated group [71.43% （55/77） vs. 28.57% （11/34）, P〈0.051, higher in T1-T2 group than in T3-T4 group [67.16% （45/ 67） vs. 47.73% （21/44）, P〈0.051, and higher in non-recurrence group than in local recurrence group [65.06% （54/83） vs. 42.86% （12/28）, P〈0.05]. CONCLUSIONS： The lower pathologic degree and higher T stage of glottic squamous cell carcinoma, the lower expression of CD1a^＋ DCs. The positive rate of CD1a^＋ DCs is low in recurrent glottic tumor. High expression of CDla^＋ DCs may indicate better prognosis of glottic squamous cell carcinoma.

关 键 词：喉肿瘤 癌 鳞状细胞 树突细胞 CD1a表达 免疫组化 预后 

分 类 号：R739.65[医药卫生—肿瘤]