转化生长因子-β_1在慢性硬化性颌下腺炎中的表达及意义  

Expression and significance of transforming growth factor-β_1 in chronic sclerosing sialadenitis of the submandibular gland

作　　者：刘颖 姜晓钟[2] 李玉莉[3] 赵云富[2] 

机构地区：[1]济南军区总院口腔科,250031 [2]上海长征医院口腔科 [3]上海长征医院病理科

出　　处：《现代口腔医学杂志》2005年第5期482-485,共4页Journal of Modern Stomatology

摘　　要：目的探讨转化生长因子-β1(transforminggrowthfactor-β1,TGF-β1)在慢性硬化性颌下腺炎中的表达及其与颌下腺纤维化之间的关系。方法收集慢性硬化性颌下腺炎患者44例,根据颌下腺纤维化程度分期分为四组,用免疫组织化学方法分别观察四组中的TGF-β1、Ⅰ型胶原(collagenⅠ,COL-Ⅰ)和纤维连接蛋白(fibronectin,FN)的表达,并与正常组对照,用图像分析仪测定单位面积阳性颗粒百分比并进行统计学分析。结果TGF-β1、COL-Ⅰ和FN的表达量均与颌下腺的病变程度成正比(各组均P<0.05);此外TGF-β1与COL-Ⅰ、FN的表达量成正相关(各组均P<0.01)。结论随着慢性硬化性颌下腺炎病变程度的加重,TGF-β1表达显著增加,它可能通过促进细胞外基质(extracellularmatrix,ECM)主要成分如COL-Ⅰ、FN等合成的增加,而参与颌下腺纤维化发生,并在颌下腺纤维化形成过程中起重要作用。Objective To study the expression and significance of TGF-β1 in chronic sclerosing sialadenitis of the submandibular gland. Methods Expression of transforming growth factor-β1 （TGF -β1）, collagen Ⅰ （COL - Ⅰ ）, and fibronectin （FN） were investigated with immunohistochemistry assays in 44 patients with chronic sclerosing sialadenitis of submandibular gland. These patients were graded into four- degree groups according to the extent of fibrosis. Results The study found that the expression intensity of TGF-β1 ,COL- Ⅰ,and FN was correlated to the fibrotic grade of the subrnandibular gland （ P 〈0.05）. The expression of TGF-β1 in subrnandibular injured area was correlated with that of the COL - Ⅰ（ P 〈 0.01 ） and FN （ P 〈 0.01 ）. Conclusion The increased expression of TGF-β1 may play an important role in the development and progression of the submandibular fibrosis by increasing the synthesis and accumulation of extracellular matrix （ECM）.

关 键 词：慢性硬化性颌下腺炎 纤维化 转化生长因子-Β 细胞外基质 

分 类 号：R781.72[医药卫生—口腔医学]