肺癌患者FLK-1和LRP的实验与临床研究  

Experimental and clinical investigation of FLK-1 and LRP in human primary lung cancer

作　　者：朱春荣[1] 夏学鸣[1] 王庆才[1] 康苏娅[1] 

机构地区：[1]苏州大学第一附属医院肿瘤科

出　　处：《临床肿瘤学杂志》2005年第4期353-356,共4页Chinese Clinical Oncology

摘　　要：目的:探讨血管内皮生长因子受体FLK1和肺耐药蛋白LRP基因在肺癌发生发展过程中的作用。方法:用免疫组化技术(ABC法)对原发性肺癌组织中二种基因的表达进行检测。结果:70例肺癌中,非小细胞肺癌LRP过度表达率为69.5%,明显高于小细胞肺癌LRP过度表达率27.3%(P<0.05);腺癌中LRP的表达明显高于鳞癌(P<0.05)。LRP与FLK1在59例NSCLC中共同表达29例(49.2%),LRP的表达与肺癌的组织学分级、吸烟以及组织学类型有关;FLK1与TNM分期相关,均有统计学意义(P<0.05)。FLK1+LRP、中药治疗、复发与患者的预后有关(P<0.05)。结论:FLK1和LRP基因蛋白产物的检测对肺癌患者的诊治和预后评估有积极意义。Objective：To investigate the effect of FLK-1 and LRP genes in the carcinogenesis and development of lung cancer. Methods：The expression of FLK-1 and LRP gene proteins in primary lung tumors was studied immunohistochemically. Results：Of the 70 lung cancers, the overexpression of LRP in NSCLCs was 69.5% and 27.3% in SCLCs,There was statistically significant correlation （ P 〈 0. 05 ）. The squamouscarcinoma was significantly different （ P 〈 0. 05 ） from adenocarcinoma in the positive rate of LRP. The co-expression rate of LRP with FLK-1 in 59 cases NSCLCs was 49.2%. There was significant correlation between the expression of LRP and histological grade, smoke and histological type, the expression of FLK-1 and TNM staging （ P 〈 0. 05 ）. FLK-1, and LRP genes showed co-expression in some of the lung tumors. In a multivariate analysis by Cox regression model, the overexpression of FLK-1 ＋ LRP, the traditional Chinese Medical therapy and recurrence were independently associated with patient prognosis （ P 〈 0.05 ）. Conclusion：The detection of FLK-1 and LRP geneproteins has positive effects on diagnosis,prognosis and treatment of lung cancer.

关 键 词：肺癌 FLK-1基因 LRP基因 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]