直肠癌术后复发组织间插植放射治疗探讨  

Preliminary experience of interstitial brachytherapy for local recurrence of rectal cancer

作　　者：吴君心[1] 潘建基[1] 刘秀英[1] 郭福榕[1] 

机构地区：[1]福建省肿瘤医院放疗科

出　　处：《临床肿瘤学杂志》2005年第4期357-358,共2页Chinese Clinical Oncology

摘　　要：目的:探讨直肠癌术后复发的组织间插植放射治疗技术及疗效。方法:1996年2月～1998年10月本院治疗直肠癌Miles术后会阴部局部复发10例,其中伴阴道受侵3例。体外照射40～50Gy后行组织间插植高剂量率192Ir后装治疗,施源管5～25根,剂量3～10Gy/次,总量26～30Gy。结果:CR3例,PR5例,PD2例。2例在治疗后出现局部复发,2例出现会阴部放射性溃疡,均为10Gy/次的患者。3年生存率60%(6/10),其中2例带瘤生存。结论:组织间插植放射治疗是直肠癌术后复发的有效治疗方法,高剂量率放射治疗的分次剂量不宜过高,尤其是会阴皮肤及阴道受侵者。Objective： To study the technique and effect of interstitial brachytherapy for local recurrence of rectal cancer. Methods：From February 1996 to October 1998,ten patients of rectal cancer with recun＇ence at perineum were treated with interstitial brachytherapy. After 40～54Gy of external irradiation,the interstitial brachytherapy was administered by using HDR Ir-192 afterloading technique. The total doses were 26～30Gv with 3 ～10Gy per fraction. The number of catheters ranged from 5～25. Results：3 patients reached CR,5 patients PR and 2 patients PD. The 3-year survival rate was 60%. Deep radiation ulcer occurred in 2 patients,both of them were treated with 10Gy per fraction. Conclusion： Interstitial brachtherapy is a effective treatment for local recurrence of rectal cancer. However,the dose fractionation schedule should be carefully chosen,too high dose per fraction is not suitable.

关 键 词：直肠肿瘤 复发 放射治疗 铱放射性同位素 

分 类 号：R735.37[医药卫生—肿瘤] R730.55[医药卫生—临床医学]