皮肤鳞癌中三标志物的表达及其临床意义  

Expressions and Clinical Significance of Survivin, bcl-2 and PCNA in Cutaneous Squamous Cell Carcinoma

作　　者：陈海洲[1] 邹继彬[1] 

机构地区：[1]广东省湛江中心人民医院皮肤科,广东湛江524037

出　　处：《中国医师杂志》2005年第9期1185-1187,共3页Journal of Chinese Physician

摘　　要：目的研究survivin(SVV)、bcl-2基因蛋白和增殖细胞核抗原(PCNA)在皮肤鳞癌(SCC)中的表达。方法用免疫组化SP法检测82例SCC组织和18例正常皮肤组织中的SVV、bcl-2基因蛋白和PCNA的表达水平。结果正常皮肤无SVV表达,SCC中阳性率为79.3%(P<0.01);且阳性率与组织分化、分期、转移和预后有关。癌组织bcl-2阳性率为58.5%,高于正常皮肤的16.7%(P<0.01);bcl-2阳性率与组织分化有关,与分期、转移和预后无关。SVV与PCNA呈正相关,与bcl-2无关。bcl-2与PCNA呈负相关。结论SVV和bcl-2在SCC的发生、发展中通过不同途径起作用,检测SVV对SCC的早期诊断、恶性程度判断、预测预后有作用。Objective To evaluate the expressions and roles ofsurvivin （SVV）, bcl-2 and proliferatingcell nuclear antigen（PCNA） incutaneous squamous cell carcinoma （SCC）. Methods The expressions of SVV, bcl-2 and PCNA were investigated by SP immunohistnehemistry technique in 82 cases of SCC and 18 normal skin samples. Results There were 79.3% of SCC patients with the expression of SVV （P〈0.01）, and no in normal skin samples. The positive rate of SVV expression in SCC was related to differentiation, clinical-stages, metastasis and prognosis. The positive rate of bcl-2 in SCC （58.5%） was higher than that in normal skin samples （16.7%, P〈0.01）. The expression of bcl-2 in SCC was related to differentiation, but not to clinical-stages, metastasis and prognosis. The expression of SVV in SCC had a parallel relationship with PCNA and had no relationship with bcl-2. The expression of bcl-2 was negatively associated with PCNA. Conclusion SVV and bcl-2 may play certain roles in the oncogenesis and progression of SCC by different mute and the detection of SVV may be helpful for the earlier diagnosis and prognosis in SCC.

关 键 词：皮肤肿瘤 survivin bcl-2 PCNA 皮肤鳞癌 增殖细胞核抗原(PCNA) BCL-2基因蛋白 临床意义 正常皮肤组织 标志物 

分 类 号：R739.5[医药卫生—肿瘤] R737.31[医药卫生—临床医学]