2-苯基-1,2-苯并异硒唑-3-(2H)-酮的合成研究  

Synthesis of 2-Phenyl-1, 2-Benzisoselenazol-3- (2H)-one

作　　者：颜雪明[1] 卢志强[2] 阳鹏飞[1] 

机构地区：[1]南华大学化工学院,湖南衡阳421001 [2]洛阳师范学院化学系,河南洛阳471600

出　　处：《精细化工中间体》2005年第4期22-23,27,共3页Fine Chemical Intermediates

摘　　要：在N2保护下,采用水合肼的碱性水溶液还原硒粉制备了K2Se2,不经分离直接与邻氨基苯甲酸的重氮盐反应得到了中间体2,2'-二硒化苯甲酸;在环合反应合成2-苯基-1,2-苯并异硒唑-3-(2H)-酮(Ebselen)时改用了乙醚-水为反应体系,K2CO3水溶液作为副产物HCl的吸收剂,促使胺解关环反应顺利进行,产物易分离、纯化得2-苯基-1,2-苯并异硒唑-3-(2H)-酮。The basic solution of Na2Se2 was obtained from reaction of selenium and hydrazine hydrate in the basic solution under the protection of nitrogen, and then reacted directly with salt solution of diazotization of oaminobenzoie acid to give the intermediate 2,2＇-bisselanyldibenzoie acid in a good yield. The eyelization of 2,2＇- bisselanyldibenzoie acid with aniline in the ether-water system gave the product 2-phenyl-1, 2- benzisoselenazol-3 （2H）-one using potassium carbonate as the absorbent of hydrochloric acid, which had a characteristics of easy separation and purification of the product.

关 键 词：硒 邻氨基苯甲酸 2 2’-二硒化苯甲酸 2-苯基-1 2-苯并异硒唑-3-(2H)-酮 合成 

分 类 号：TQ252[化学工程—有机化工]