精神分裂症患者治疗后多项诱发电位的变化  

A comparative study of brain evoked potentials in schizophrenia

作　　者：朱锐明 胡纪明 赵俊雄 

机构地区：[1]金华市第二医院精神科,321016

出　　处：《上海精神医学》2005年第4期225-227,共3页Shanghai Archives of Psychiatry

摘　　要：目的了解精神分裂症患者P300、听觉诱发电位(AEP)和脑干听觉反应(ABR)的特征以及治疗前后诱发电位的变化。方法应用美国Nicolet Spirit脑诱发电位仪,记录34例精神分裂症患者和31名正常成人的P300、AEP和ABR,于治疗6个月时进行P300、AEP和ABR随访。结果1.与NC 组比较,精神分裂症组三项诱发电位主成份(P300-P3靶潜伏期、AEP-P2潜伏期和ABR-波V波幅) 延迟,波幅降低(P<0.05-0.01)。2.随访提示:P300中的P3靶潜伏期和波幅,AEP中的P2潜伏期和波幅以及ABR中的波Ⅲ潜伏期和波V波幅改变可能是属于该疾病的状态标志。结论本组精神分裂症患者的诱发电位变化为状态标志,多项诱发电位指标联合应用可作为精神分裂症治疗监测的有用指标。Objective： To investigate the brain voked potentials （BEPs） of schizophrenia patients in episodic and remitted state. Methods： Cognitive potentials P300（P300）, auditory evoked potential （AEP） and auditory brainstem response （ABR） were recorded from 34 schizophrenia patients using a Nicolet Spirit Instrument, and compared with that of 31 normal controls （NC）. Some schizophrenia patients were followed up by 6 months with the samemarkers. Results： 1. Compared with NC, schizophrenia patients showed delayed latency and decreased amplitude of BEP s, P3 of P300 and P2 of AEP Latencies , and decreased Vamplitude of ABR. 2. The following up measures of evoked potentials suggested that latency and amplitude of P3/P300, P2 of AEP latency and amplitude, and wave Ⅲ and wave V of ABR might be state markers of Schizophrenia. Conclusion ：The clinical application of brain evoked potentials in schizophrenia is emphasized.

关 键 词：认知电位P300 听觉诱发电位 脑干听觉反应 精神分裂症 精神分裂症患者 多项诱发电位 治疗后 P300 脑诱发电位仪 SPIRIT 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R651.150.4[医药卫生—临床医学]