低浓度铅环境作业工人周围神经传导速度与生物学指标的变化(英文)  

Changes in the nerve conducting velocity and biological indices of workers exposed to low-concentration lead

作　　者：朱玉华[1] 周敏杰[2] 曹钟兴[1] 田月秋[1] 吴公孙[1] 李健[1] 

机构地区：[1]上海第二医科大学新华医院职业病科,上海市200092 [2]上海第二医科大学新华医院电生理科,上海市200092

出　　处：《中国临床康复》2005年第29期227-229,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:在国家最高容许铅浓度范围内作业长期接触铅时,是否仍可对人体健康产生影响?目的:调查分析低浓度铅作业工人周围神经传导速度和生物学指标的变化。设计:以低浓度铅作业工人为观察对象的检验。单位:上海第二医科大学新华医院职业病科及电生理科。对象:以2000-09/2002-10上海第二医科大学附属新华医院职业病科职业健康体检的铅作业工人和同地科室人员为调查对象,共106例。接触组为热处理工人66人,对照组为同期同地科室人员40人。方法:采用问卷调查和实验室检查对接触组和对照组进行周围神经传导速度和生物学指标血铅、血锌原卟啉、游离原卟啉、血红蛋白的检测。对检测数据进行相对危险度分析。主要观察指标:①接触组和对照组周围神经传导速度。②各项生物学指标变化。结果:进入结果分析106人,对照组40人,接触组66人,接触组中工龄>10年34例,<10年32例。①接触组工龄>10年工人周围神经运动传导速度中正中神经比对照组加快犤(50.11±4.76),(47.59±4.86)m/s,P<0.05犦,尺神经比对照组加快犤(63.11±2.58),(61.83±3.03)m/s,P<0.05犦。②接触组工龄>10年工人血铅高于<10年工人犤(0.568±0.28),(0.425±0.31)μmol/L,P<0.05犦,接触组工龄>10年工人血游离原卟啉高于<10年工人犤(2.24±0.32),(2.09±0.27)μmol/L,P<0.05犦,接触组工龄>10年工人尿铅高于<10年工人犤(0.087±0.008),(0.083±0.007)mg/L,P<0.05犦。接触组工龄>10年工人血锌原卟啉为(1.42±0.33)μmol/L,高于接触组工龄<10年工人犤(1.25±0.35)μmol/L,P<0.05犦及对照组犤(1.22±0.44)μmol/L,P<0.05犦。接触组工龄>10年工人血红蛋白为(12.26±4.5)g/L,低于接触组工龄<10年工人犤(14.55±4.81)μmol/L,P<0.05犦及对照组犤(14.88±4.30)μmol/L,P<0.05犦。③接触组工龄<10年工人周围神经感觉传导异常1例,异常率3%(1/32),接触组工龄>10年工人4例,异常率12%(4/34)。接触组工龄<10年BACKGROUND： Whether long time exposure to the lead concentration which is within the state allowed range will cause any bad effects on people＇ s health？ OBJECTIVE： To investigate the nerve conducting velocity （NCV） and other biological indices of workers who are exposed to low concentration lead. DESIGN： It was an investigation and the subjects were workers exposed to low concentration lead. SETTING： Occupational Disease Department and Electrophysiological Department of Xinhua Affiliated Hospital of the Shanghai Second Medical University. PARTICIPANTS： In lead contact group were 66 heat treatment workers who were exposed to lead and received physical examination from September 2000 to October 2002. In control group were 40 office workers that worked at the same factory but were not exposed to lead. METHODS： Questionnaire and laboratory examination were adopted for measurement of NCV and other biological indices like blood lead, blood zinc protoaetioporphyrin （ZPP）, blood free protoporphyrin （FPP） and hemoglobin content in the two groups. And the relative risk analysis was conducted. MAIN OUTCOME MEASURES： ① The NCV in both groups. ② The biological indices in both groups. RESULTS： All the 106 subjects entered analysis stage. In lead contact group there were 34 workers of more than 10 working years and the other 32 workers of less than 10 working years. ① The NCVs of median and ulnar nerve in those of over 10 working years were faster than those in control group [（50.11 ±4.76） m/s, （63.11 ±2.58） m/s vs （47.59±4.86） m/s, （61.83±3.03） m/s, P〈 0.05]. ② In lead contact group the blood lead level of those of over 10 working years was higher than those of less than 10 years [（0.568±0.28）, （0.425±0.31） μmol/ L, P 〈 0.05]. So was the FPP level [（2.24±0.32）, （2.09±0.27）μmol/L, P 〈 0.05] and urine lead level [（0.087±0.008）, （0.083±0.007）μmg/L, P 〈 0.05]. The ZPP level of those of over 10 working years was also higher than tho

关 键 词：铅 神经传导 生物学 

分 类 号：R745[医药卫生—神经病学与精神病学]