应用微核试验观察硒抗氯化汞的诱变效应  

ASTUDY ON THE EFFECT OF SELENIUM ON THE MERCURIC CHLORIDE INDUCED MUTAGENESIS BY MICRONUCLEAR TESTS OF THE BONE MARROW CELLS IN MICE AND RATS

作　　者：孙媛霞[1] 杨玉林[1] 张颖[1] 都昌杰[1] 郭荣昌[1] 韩晓辉 李华[1] 

机构地区：[1]东北农业大学,黑龙江省畜牧兽医学校

出　　处：《东北农业大学学报》1996年第1期50-53,共4页Journal of Northeast Agricultural University

摘　　要：通过应用大鼠和小鼠骨髓细胞微核测试法，观察了富含硒的植物──大豆、硒及汞化合物对鼠的单独和联合的诱变效应．实验结果表明，氯化汞和亚硒酸钠均能单独引起鼠的骨髓嗜多染红细胞的微核率明显升高．当硒、汞联合作用时，亚硒酸钠对氯化汞可有明显的抗诱变能力．In order to study the mutagenic effects of combined exposure and single exposure to selenium and mercuric chloride, we examined the frequency of micronucleated PCE in the bone marrow of mice and rats.The results indicated that selenium and mercuric chloride both caused the increase in micronucleus frequency in the bone marrow of mice and rats.The differences between the treated and the controls as statistically significant (P<0.01). The results obtained also showed that both selenium and selenium-containing soybean can apparently decrease the micronuleus frequency induced by mercuric chloride.This demonstrated that selenium and mercuric chloride had the mutagenic effect when they were used alone, and selenium was effective in inactivating the mutagenicity of mercuric chloride when selenium or selenium-containing soybean were used together with mercuric chloride.

关 键 词：硒 大豆 亚硒酸钠 氯化汞 诱变效应 微核试验 

分 类 号：Q2－33[生物学—细胞生物学] R730.1[医药卫生—肿瘤]