锌孵育对肝豆状核变性离体培养细胞内铜、锌和金属硫蛋白代谢的影响  

Influence of zinc incubation on copper, zinc and metallothionein metabolism in cultured skin fibroblasts of Wilson's disease

作　　者：陈嵘[1] 梁秀龄[1] 刘焯霖[1] 张影如[1] 陈彪[1] 

机构地区：[1]中山医科大学附属第一医院神经科

出　　处：《中国神经精神疾病杂志》1996年第1期13-15,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：卫生部重点科研基金

摘　　要：本实验研究了锌孵育后肝豆状核变性患者和杂合子离体培养皮肤成纤维细胞内铜、锌和金属硫蛋白（ＭＴ）代谢的改变，以及经４５．８８μｍｏｌ／Ｌ锌孵育后，患者胞浆内钢含量增高，同时ＭＴ上的钢结合量也增高，但ＭＴ含量无明显变化，根据上述结果，对锌剂治疗本病的作用机理进行了初步讨论。The copper, zinc and metallothionein (MT)metabolism in cultured skin fibroblalsts of heterozygotCs and patient with Wilson's disease (hepatolenticular degeneration), together with controls after zin cincubation, were studied. It was found that the copper contents in cytosol and MT fractions of patiellts were elevated after zinc incubation, while the MT contellts in thxee groups remained unchanged.According to the results, the mechanism of zing therapy for Wilson's disease' was discussed in this article.

关 键 词：肝豆状核变性 离体培养 锌剂 铜 金属硫蛋白 

分 类 号：R742.4[医药卫生—神经病学与精神病学]