输尿管癌单纯手术与术后辅助放疗的对照分析  

Validity of Postoperative Radiotherapy in Transitional Cell Carcinoma of the Upper Urinary Tract

作　　者：陈兵[1] 王国民[2] 张立[2] 曾昭冲[1] 

机构地区：[1]复旦大学附属中山医院放疗科,上海200032 [2]复旦大学附属中山医院泌尿外科,上海200032

出　　处：《中国临床医学》2005年第4期641-643,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨输尿管移行细胞癌术后辅助放疗的疗效。方法:回顾性分析46例输尿管移行细胞癌(术后辅助放疗24例,未行术后放疗22例)临床资料。24例术后放疗病例中,15例行全尿路放疗,9例行输尿管局部放疗。结果:术后局部放疗和全尿路放疗的局控率分别为22.22%和80%,有显著差异(P<0.05)。全尿路放疗和单纯手术组的局控率分别为80%和45.45%,亦有显著差异(P=0.036)。两组生存率无显著差异。结论:输尿管移行细胞癌术后应给予辅助放疗。术后辅助放疗应采用全尿路放疗。Objective： To evaluate the role of postoperative adjuvant radiation therapy in transitional cell carcinoma of the upper urinary tract. Methods： We retrospectively reviewed a series of 46 patients between February, 1998 and June,2004. Twenty four patients underwent surgery followed by radiation therapy to a total dose of 50 Gy / 25Fx, only to the tumor bed in 9 patients, to the tumor bed and its regional nodes and bladder in 15 patients. Results： After a mean followup of 46 months,7 in 9 patients who treated only to the tumor bed and 3 in15 patients who underwent surgery followed by radiation therapy to the renal bed/ureteral bed/bladder experienced locoregional failure（78% vs 20% ,P = 0. 005）. And 12 in 22 patients without adjuvant radiotherapy experienced locoregional failure（55% vs 20% ,P = 0. 036）. Five-years overall survival rates with or without adjuvant radiotherapy were 52.54% and 26. 64% ,P = 0. 431. Conclusion：Our series suggests that the patients suffered with transitional cell carcinoma of the upper urinary tract need a postoperative radiation therapy, the radiotherapy should be treated to the renal bed/ureteral bed/bladder.

关 键 词：输尿管肿瘤 放疗 生存分析 

分 类 号：R737.13[医药卫生—肿瘤]