沙培林对脾切除后实验性胃癌大鼠免疫杀伤细胞的活性作用  

The effect of combined splenectomy on the immune function of experimental rats with gastric cancer of OK-432

作　　者：丁尔迅[1] 王元和[1] 高瀚[1] 徐学俊[1] 孔宪涛[2] 徐建明[3] 张玲珍[2] 张浩[2] 

机构地区：[1]第二军医大学长征医院普外科,上海200003 [2]第二军医大学长征医院临床免疫中心,上海200003 [3]第二军医大学长征医院化学教研室,上海200003

出　　处：《中华实验外科杂志》1996年第1期9-9,共1页Chinese Journal of Experimental Surgery

摘　　要：通过观察沙培林(OK-432)对脾切除后胃癌大鼠免疫杀伤的细胞作用,发现OK-432小剂量长期治疗后,外周血淋巴细胞(PBL)的NK和ADCC细胞活性分别显著高于生理盐水非治疗组。OK-432治疗同时保留脾脏,PBL的NK和ADCC细胞活性更加显著地高于切脾非免疫治疗组。在OK-432腹腔注射大鼠中,模拟切脾组的PBL的NK和ADCC的细胞活性均高于切脾组。提示在腹腔注射OK-432治疗中,保留脾脏有提高免疫杀伤细胞活性的趋势。Effects of OK-432 on the immune func- tion of cytotoxic cells of experimental rats with gastric cancer treated by combined splenectomy were studied. It was found that cytotoxicities of NK and ADCC of peripheral blood lymphocytes (PBL) after treatment with small doses of OK-432 for a long period were significantly higher than those treated with normal saline. Cytotoxicities of NK and ADCC of PBL treated by OK-432 with spleen conserved were significantly higher than those of non-immune treatment plus combined splenectomy. Cytotoxicities of NK and ADCC of PBL of sham-splenectomy were higher than those of combined splenectomy among rats treated with intraperitoneal injection of OK- 432. It is suggested that conservation of spleen could increase cytotoxicities of immune cyto- toxic cells during treatment with intraperi- toneal injection of OK-432.

关 键 词：沙培林 胃肿瘤 脾切除 免疫杀伤细胞 

分 类 号：R735.203[医药卫生—肿瘤] R657.605[医药卫生—临床医学]