复方酸枣仁安神胶囊治疗失眠症的疗效观察及药理研究  

Observation on Efficacy and Experimental Study with Compound Suanzaoren Ansen(酸枣仁安神)Capsules for Insomnia

作　　者：马有度[1] 李荣亨[1] 陶元津[1] 孙立仁[1] 胡光志[1] 刘岳风 邓文龙[2] 

机构地区：[1]重庆医科大学第二附属医院中医科 [2]四川省中药研究所药理室

出　　处：《中西医结合杂志》1989年第2期85-87,68-69,共3页

摘　　要：对374例失眠患者随机分为复方酸枣仁安神胶囊、朱砂安神丸及安眠酮3组治疗。总有效率分别为84.15%,67.06%及81.61%。结果表明,复方酸枣仁安神胶囊疗效优于朱砂安神丸(P<0.005),而与安眠酮相仿(P>0.05)。睡眠脑电图及动物实验表明,复方酸枣仁安神胶囊疗效可靠,作用迅速,安全无毒。374 patients suffering from insomnia were divided into three groups by random:202 cases in group Ⅰ were treated with compound Suanzaoren Ansen capsules(SAC);85 cases in group Ⅱ were treated with Zhusha Ansen(硃砂安神)pills(ZAP)as control;87 cases in group Ⅲ were treated with Methaqualone(Hyminal)also as control.The therapeutic results were as follows:Groups Ⅰ,Ⅱ and Ⅲ snowed significant effective rates of 49.50%,18.82% and 32.18% respectively;moderate effective rates of 34.65%,48.24% and 49.43% respectively;and total rates of effectiveness of 84.15,67.06% and 81.61% respectively.The authors found significant statistical difference between group Ⅰ and Ⅱ(P< 0.005)and of no statistical difference between group Ⅰ and Ⅲ(P>0.05).The results showed that the effects of compound SAC were better than ZAP,and similar to that of methaqualone.EEG analysis carried out while sleeping confirmed the effects mentioned above.Low toxicity(LD_(50)10.7 g/kg)of compound SAC was found through animal experimentations.No towards reactions were revealed in clinical trials except nausea in 3 cases.Heart rate and blood pressure changed lightly in a few cases.

关 键 词：失眠症 酸枣仁 安神胶囊 

分 类 号：R749.705[医药卫生—神经病学与精神病学]