Level of proinsulin in association with cardiovascular risk factors and sleep snoring  

作　　者：En-Zhi Jia Zhi-Jian Yang Shi-Wei Chen Guang-Yao Qi Chun-Fa You Jian-Feng Ma Jing-Xin Zhang Zhen-Zhen Wang Wei-Chong Qian Hai-Yan Wang Wen-Zhu Ma 

机构地区：[1]Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [2]The Disease Control Center of Pizhou City, Pizhou 221300, Jiangsu Province, China [3]Department of Central Clinical Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [4]Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

出　　处：《World Journal of Gastroenterology》2005年第32期5047-5052,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No. 30400173

摘　　要：AIM: To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep snoring.METHODS: Based on the random stratified sampling principle, 1 193 Chinese residents in Pizhou City, Jiangsu Province (530 males and 663 females, aged 35-59 years with an average age of 46.69 years) were recruited. Their sleep snoring habits were investigated. Biotin-avidin based double mAbs ELISA was used to detect specific insulin and proinsulin, and a risk factor score was established to evaluate the individuals according to the number of their risk factors.RESULTS: The results of Spearman correlation analysis and covariate ANOVA analysis after age and sex were controlled, indicated that not only the level of proinsulin (r = 0.156, P = 0.000, F= 5.980 P = 0.000), but also cardiovascular risk factors score (r = 0.194, P = 0.000,F= 11.135, P = 0.000) significantly associated with the frequency of sleep snoring, and the significant relationship between true insulin and frequency of sleep snoring was only shown in the covariate ANOVA analysis (F = 2.868,P = 0.022). The result of multivariate stepwise logistic regression after age, sex, body mass index, waist circumference and true insulin were controlled showed that proinsulin (division by interval of quartile) was an independent risk factor for sleep snoring (OR = 1.220,95%CI: 1.085-1.373, P = 0.001).CONCLUSION: The interaction of cardiovascular risk factors clustering, high proinsulin level and sleep breathing disorder may be a syndrome, which has not been recognized in human beings so far.AIM： To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep snoring. METHODS： Based on the random stratified sampling principle, 1193 Chinese residents in Pizhou City, Jiangsu Province （530 males and 663 females, aged 35-59 years with an average age of 46.69 years） were recruited. Their sleep snoring habits were investigated. Biotin-avidin based double mAbs ELISA was used to detect specific insulin and proinsulin, and a risk factor score was established to evaluate the individuals according to the number of their risk factors. RESULTS： The results of Spearman correlation analysis and covariate ANOVA analysis after age and sex were controlled, indicated that not only the level of proinsulin （r = 0.156, P = 0.000, F= 5.980 P = 0.000）, but also cardiovascular risk factors score （r = 0.194, P = 0.000, F= 11.135, P= 0.000） significantly associated with the frequency of sleep snoring, and the significant relationship between true insulin and frequency of sleep snoring was only shown in the covariate ANOVA analysis （F= 2.868, P = 0.022）. The result of multivariate stepwise logistic regression after age, sex, body mass index, waist circumference and true insulin were controlled showed that proinsulin （division by interval of quartile） was an independent risk factor for sleep snoring （OR = 1.220, 95%CI： 1.085-1.373, P = 0.001）.CONCLUSION： The interaction of cardiovascular risk factors clustering, high proinsulin level and sleep breathing disorder may be a syndrome, which has not been recognized in human beings so far.

关 键 词：True insulin PROINSULIN SNORING EPIDEMIOLOGY 

分 类 号：R54[医药卫生—心血管疾病] R766.43[医药卫生—内科学]