PROINSULIN

作品数:12被引量:34H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:吕秀芳孟庆宇金秀东李光伟孙庭万更多>>
相关机构:北京大学牡丹江医学院中日友好医院厦门大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Science Bulletin》《China Medical Abstracts(Internal Medicine)》更多>>
相关基金:国家自然科学基金更多>>
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Correlation between proinsulin,true insulin and insulin resistance in patients with type 2 diabetes mellitus
《China Medical Abstracts(Internal Medicine)》2021年第1期26-26,共1页YAO Jiali 
Objective To investigate the relationship between proinsulin (PI),true insulin (TI) and insulin resistance(IR) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 107 T2DM hospitalized patients were se...
关键词:T2DM PATIENTS MELLITUS 
RablA mediates proinsulin to insulin conversion in 13-cells by maintaining Golgi stability through interactions with golgin-84被引量:3
《Protein & Cell》2016年第9期692-696,共5页
Dear Editor,Insulin plays a critical role in mammalian glucose home- ostasis, and dysfunctional insulin secretion results in dia- betes. Insulin maturation in pancreatic β cells can be generally divided into three st...
葡萄糖可调控pSS—SPCAD—proinsulin载体的构建及鉴定
《中国实用医刊》2009年第8期61-62,共2页刘艳霞 胡平 栗夏连 
河南省医学高新技术发展和扶植项目(2006003)
目的构建一葡萄糖可调控pSS—SPCAD—proinsulin表达载体,模仿胰岛B细胞生理功能。方法从Phlns—ABC扩增出SS和proinsulin,与pEGFP—N1,一人工合成多核苷酸(SPCAD),通过酶切、连接、转化,构建出pSS—SPCAD—proinsulin载体。结果...
关键词:葡萄糖调控性胰岛素分泌 胰岛素基因治疗 葡萄糖反应蛋白-78 条件结A/解离区域 
Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population
《Acta Pharmacologica Sinica》2008年第6期736-744,共9页Jie WANG Yun ZHANG Zhi-jian YANG Tie-bing ZHU Lian-sheng WANG Bo CHEN Ke-jiang CAO Jun HUANG Wen-zhu MA En-zhi Jim 
Project supported by the National Natural Science Foundation of China (No 30400173).
Aim: To explore the association between 801C〉T and 847C〉T polymorphisms of the human carboxypeptidase E (CPE) gene exon5, which could cause hyperproinsulinemia, and the angiographical characteristics of coronary ...
关键词:carboxypeptidase E gene POLYMORPHISM coronary atherosclerosis Gensini's score PROINSULIN Chinese 
地黄水提液对2型糖尿病大鼠proinsulin基因表达的影响被引量:16
《中药材》2008年第3期397-399,共3页孟庆宇 吕秀芳 金秀东 
目的:探讨地黄水提液治疗2型糖尿病(2-DM)的分子生物学机制。方法:以半定量RT-PCR法和SDS-聚丙烯酰胺凝胶电泳法分别检测胰岛素原(proinsulin)基因转录及翻译水平的表达。同时观察空腹血糖(FPG)、空腹胰岛素(FINS)的含量,计算胰岛素分...
关键词:地黄水提液 2型糖尿病 胰岛素原 基因表达 
Human Proinsulin C-peptide from a Precursor Overexpressed in Pichia pastoris被引量:1
《Acta Biochimica et Biophysica Sinica》2006年第8期586-592,共7页Yang-Bin HUANG Jiang LI Xin GAO Jiu-Ru SUN Yi LU Tao FENG Jian FEI Da-Fu CUI Qi-Chang XIA Jun REN You-Shang ZHANG 
In this article we report the production of human proinsulin C-peptide with 31 amino acid residues from a precursor overexpressed in Pichia pastoris. A C-peptide precursor expression plasmid containing nine C-peptide ...
关键词:PROINSULIN C-PEPTIDE Pichia pastoris 
Level of proinsulin in association with cardiovascular risk factors and sleep snoring
《World Journal of Gastroenterology》2005年第32期5047-5052,共6页En-Zhi Jia Zhi-Jian Yang Shi-Wei Chen Guang-Yao Qi Chun-Fa You Jian-Feng Ma Jing-Xin Zhang Zhen-Zhen Wang Wei-Chong Qian Hai-Yan Wang Wen-Zhu Ma 
Supported by the National Natural Science Foundation of China,No. 30400173
AIM: To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep snoring.METHODS: Based on the random stratified sampling principle, 1 193 Chinese residents in Pizhou City, J...
关键词:True insulin PROINSULIN SNORING EPIDEMIOLOGY 
Significant association of insulin and proinsulin with clustering of cardiovascular risk factors被引量:1
《World Journal of Gastroenterology》2005年第1期149-153,共5页En-ZhiJia Zhi-JianYang Shi-WeiChen Guang-YaoQi Chun-FaYou Jian-FengMa Jing-XinZhang Zhen-ZhenWang Wei-ChongQian Xin-LiLi Hai-YanWang Wen-ZhuMa 
AIM: To investigate the association between true insulin and proinsulin and clustering of cardiovascular risk factors.METHODS: Based on the random stratified sampling principles, 1196 Chinese people (533 males and 663...
关键词:True insulin PROINSULIN Cardiovascular diseases 
Studies on the Renaturation with Simultaneous Purification of Recombinant Human Proinsulin with Unit of Simultaneous Renaturation and Purification of Protein in Semi-preparative Scale
《Chinese Chemical Letters》2003年第8期824-827,共4页Quan BAI Yu KONG Xin Du GENG 
The renaturation and purification of recombinant human proinsulin (rh-proinsulin) expressed in E. coli with the unit of simultaneous renaturation and purification of protein (USRPP) in semi-preparative scale was studi...
关键词:Liquid chromatography hydrophobic interaction chromatography RENATURATION preparation recombinant human rh-proinsulin biotechnology. 
对于胰岛素敏感性指数1/(FPG×FINS)应用中某些问题的解答被引量:13
《中国糖尿病杂志》1998年第1期60-61,共2页李光伟 
关键词:糖尿病 胰岛素 敏感性指数 PROINSULIN 
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