Objective To investigate the relationship between proinsulin (PI),true insulin (TI) and insulin resistance(IR) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 107 T2DM hospitalized patients were se...
Dear Editor,Insulin plays a critical role in mammalian glucose home- ostasis, and dysfunctional insulin secretion results in dia- betes. Insulin maturation in pancreatic β cells can be generally divided into three st...
Project supported by the National Natural Science Foundation of China (No 30400173).
Aim: To explore the association between 801C〉T and 847C〉T polymorphisms of the human carboxypeptidase E (CPE) gene exon5, which could cause hyperproinsulinemia, and the angiographical characteristics of coronary ...
In this article we report the production of human proinsulin C-peptide with 31 amino acid residues from a precursor overexpressed in Pichia pastoris. A C-peptide precursor expression plasmid containing nine C-peptide ...
Supported by the National Natural Science Foundation of China,No. 30400173
AIM: To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep snoring.METHODS: Based on the random stratified sampling principle, 1 193 Chinese residents in Pizhou City, J...
AIM: To investigate the association between true insulin and proinsulin and clustering of cardiovascular risk factors.METHODS: Based on the random stratified sampling principles, 1196 Chinese people (533 males and 663...
The renaturation and purification of recombinant human proinsulin (rh-proinsulin) expressed in E. coli with the unit of simultaneous renaturation and purification of protein (USRPP) in semi-preparative scale was studi...