带神经、血管预构皮瓣动物模型的建立及研究  

Study and establishment of animal model with prefabricated flaps containing nerves and vessels

作　　者：孙占胜[1] 王伯珉[1] 王永会[1] 张云峰[1] 李连欣[1] 穆卫东[1] 陈振强[1] 

机构地区：[1]山东省立医院骨创伤科,济南250021

出　　处：《中华创伤杂志》2005年第9期672-674,共3页Chinese Journal of Trauma

基　　金：山东省卫生厅委托科研资助项目(982050106)

摘　　要：目的设计带血管、神经预构皮瓣动物模型并进行实验研究,探讨带血管、神经预构皮瓣治疗四肢严重损伤可行性。方法新西兰大耳白兔共15只,按拟植入的血管束名称分为3组:A组植入腹壁下动静脉血管束;B组植入阴部外动静脉血管束;C组植入股动静脉血管束及部分股神经。术后3周分别进行大体观察、活体皮瓣血管染色和组织学检查,观察血管神经的生长情况。结果预构皮瓣中的血管生长良好,可见少量神经纤维和轴突向远端生长。结论预构带神经、血管皮瓣是可行的,该方法克服了传统皮瓣的外形臃肿和感觉功能差的问题。Objective To design the animal model with severe extremity trauma and prefabricate flaps containing vessels and nerves so as to study the feasibility of the prefabricated flaps in treating severe extremity trauma. Methods Fifteen New Zealand white rabbits were divided into three group according to the implanted vessels, ie, Group A （ implanted with inferior epigastric artery and vein） , Group B （ implanted with the external pudendum artery and vein） and Group C （ implanted with the femoral artery, vein and nerve）. The growth condition of vessels and nerves was observed three weeks after operation by means of general investigation, stain of flap vessels and histological examination. Results The blood vessels under the prefabricated flaps survived well and some nerve fiber and axons were seen growing towards the distal end. Conclusion Prefabricated flaps with vessels and nerves are feasible for treatment of severe extremity trauma, for this method avoids problems like clumsy outline and poor sensory function of traditional flaps.

关 键 词：外科皮瓣 预构 疾病模型 动物 创伤和损伤 预构皮瓣 动物模型 带神经 带血管 四肢严重损伤 股动静脉 血管生长 

分 类 号：R-332[医药卫生]