短暂性脑缺血发作患者认知功能与脑血流量改变(英文)  

Cognitive function and hemodynamic compromise in patients with transient ischemic attacks

作　　者：解新荣[1] 曹莹[1] 郝舒亮[2] 刘建军[3] 郭新[1] 张祖民[1] 王易娟[1] 

机构地区：[1]解放军兰州军区乌鲁木齐总医院老年病科,新疆维吾尔自治区乌鲁木齐市830000 [2]解放军兰州军区乌鲁木齐总医院神经电生理室,新疆维吾尔自治区乌鲁木齐市830000 [3]解放军兰州军区乌鲁木齐总医院核磁室,新疆维吾尔自治区乌鲁木齐市830000

出　　处：《中国临床康复》2005年第32期218-220,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：短暂性脑缺血发作患者认知功能与脑血流量改变背景:有实验表明短暂性脑缺血发作后可遗留一定的认知功能障碍,提出脑血流量及其分布与认知活动关系密切的假说。目的:观察短暂性脑缺血发作患者的认知功能改变,验证其与脑血流灌注的关系。设计:病例-对照实验。单位:解放军兰州军区乌鲁木齐总医院老年病科、神经电生理室、核磁室。对象:选择2002-01/2003-06在解放军兰州军区乌鲁木齐总医院老年病科住院和门诊的短暂性脑缺血发作患者35例,均为男性,右利手,年龄45～78岁,平均(68.1±8.4)岁。对照组33例,为同期本院健康体检者。男性,均为右利手,年龄45～77岁,平均(67.8±8.6)岁。方法:应用事件相关电位、老年认知功能量表犤包括定向、识记、广度、回忆1(有无联系)、长记忆、动物名、划销与计算、分类与类同、临摹、语言和回忆2(有无关系)等11项内容,根据原始分查不同年龄组的T分转换表,消除年龄因素的影响;再根据受试者的教育水平查教育T’分表,消除教育因素的影响;这样就可根据T’分及百分位水平对受试者的认知功能进行评估,得分越低,认知功能越差犦对两组对象进行检测评估,并对短暂性脑缺血发作患者进行磁共振血管成像检查。主要观察指标:①事件相关电位检测结果。②老年认知功能量表检查结果。③脑血管磁共振血管成像检查结果。结果:35例短暂性脑缺血发作患者,33例正常体检者,均进入结果分析。①事件相关电位检测结果:短暂性脑缺血发作患者的P300潜伏期明显长于对照组犤(336.2±34.2)ms,(311.3±44.2)ms,t=5.9453,P<0.05犦。②老年认知功能量表检查结果:短暂性脑缺血发作组广度、回忆1、长记忆、动物名、计算、回忆2评分均低于对照组犤(39.7±11.9),(47.4±12.0)分;(54.5±14.8),(61.8±14.5)分;(61.1±7.8),(64.7±1.7)分;(59.4±11.0),(64.7±8.8)分;(50.0±14.7),(58.BACKGROUND： Researches suggest that transient ischemic attack （TIA） can induce cognitive dysfunction, and cerebral blood flow and its distribution are hypothesized to be closely related to cognitive activities. OBJECTIVE： To investigate the alteration of cognitive function and provide insights into its relations with cerebral perfusion in TIA patients. DESIGN： A case-control study. SETTING： Departments of Geriatrics, Electrophysiology and Magnetic Resonance of Urumqi General Hospital of Lanzhou Military Area Command of Chinese PLA. PARTICIPANTS： Totally 35 male right-handed TIA patients aged 45-78 years with an average of （68.1±8.4） years were selected from the inpatients and outpatients in the Department of Geriatrics, Urumqi General Hospital of Lanzhou Command of Chinese PLA between January 2002 and June 2003. Another 33 healthy right handed male subjects aged 45-77 years with an average of （67.8±8.6） years coming for physical examination were recruited to serve as the control group. METHODS： Patients and control subjects were tested with event-related potentials （ERPs） and the scale of elderly cognitive function （SECF） to examine the orientation, learning and memory, span, recall 1 （association）, long-term memory, naming of animals, calculation, classification, copying, language and recall 2 （relation）. According to the T score transformation table, the original scores were transformed into T scores relative to the age to eliminate the impact of age, and also into T＇score to eliminate the interference by the patients＇education, so that cognitive function of the patients could be evaluated with T＇score, and the lower the score, the poorer the cognitive function. Cases in the two groups were all tested, and TIA patients were also examined with magnetic resonance angiography （MRA）. MAIN OUTCOME MEASURES： Results of ERPs, SECF and MRA. RESULTS： Of the 35 TIA patients and 33 control subjects all completed the trial. Examination of ERPs reveled significantly pr

关 键 词：脑缺血发作 短暂性 认知 磁共振成像 

分 类 号：R749.1[医药卫生—神经病学与精神病学]