肝硬化自发性细菌性腹膜炎时血和腹水一氧化氮、内皮素变化及丹参治疗作用研究  

Changes of levels of nitric oxde,endothelin in serum and ascitic fluid and tanshionon for treatment of cirrhosis and spontaneous bacterial peritonitis

作　　者：刘建生[1] 田怡[1] 付极[1] 张晓红[1] 刘进[1] 

机构地区：[1]上海第二医科大学附属瑞金医院集团闵行医院消化科,201100

出　　处：《医师进修杂志》2005年第9期29-30,33,共3页Journal of Postgraduates of Medicine

摘　　要：目的探讨肝硬化并自发性细菌性腹膜炎(SBP)患者血清和腹水中一氧化氮(NO)、内皮素(ET)水平的变化及丹参治疗作用机制。方法肝硬化腹水并SBP 75例。随机分成两组,治疗组38例(A组)常规治疗+丹参;观察组37例(B组)予常规治疗。治疗前后测定两组患者血清和腹水的NO、ET的变化,同时选肝硬化腹水漏出液组35例(C组)作对照。结果SBP组血清和腹水的NO、ET水平明显高于漏出液组,且腹水NO、ET水平又明显高于血清中的NO、ET水平(P<0.01)。丹参组治疗后血清和腹水中NO、ET下降水平和住院天数缩短,与观察组比较均有显著性差异(P<0.01)。结论腹水NO、ET的检测有助于SBP的诊断和疗效观察。丹参是治疗SBP有效药物。Objective To study changes of nitric oxide （NO） and endothelin （TT） in the plasma and ascific fluid and tanshionon for treatment of cirrhosis and spontaneous bacterial peritonitis （SBP）. Methods Seventy - five patients with SBP, randomimental group （group A, n = 38） were given tanshionon and treated routine, and group B （ n = 37） with treated routine. NO and ET were measured by the methods in all patients and after the treatment. Group C（ n = 35） was cirrhotic patients without SBP. Results Serum and ascitic fluid NO and ET levels were high in patients with SBP as compared with those without SBP, and SBP patients NO and ET levels from ascitic fluid were superior to those from serum （ P 〈 0.01 ）. The levels of NO and ET decreased for treatment group B significant difference （ P 〈 0.01 ）. Conclusion Comparing detection of NO and ET levels from ascitic fluid is helpful to diagnosing SBP and evaluating the efficacy. Therapeutical effect posse of tanshinon in SBP.

关 键 词：肝硬化 自发性腹膜炎 一氧化氮 内皮素 丹参 肝硬化自发性细菌性腹膜炎 肝硬化腹水 治疗作用 后血清 内皮素变化 

分 类 号：R575.206[医药卫生—消化系统] R259.752[医药卫生—内科学]