丹奥联合葛根素治疗急性脑梗死的疗效观察  

Clinical Efficacy and Mechanism of Sodium Ozagrel with Puerarin in Treating Acute Cerebral Infarction

作　　者：王玉梅[1] 李合华[1] 毛兴爱[1] 

机构地区：[1]河南省新乡医学院

出　　处：《中西医结合心脑血管病杂志》2005年第9期767-769,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨急性脑梗死病人应用丹奥联合葛根素与单独应用丹奥治疗的疗效及对C反应蛋白(CRP)、内皮素(ET)和一氧化氮(NO)的影响。方法将脑梗死病人随机分为治疗组和对照组,进行临床疗效比较并动态测定血浆CRP、ET和NO浓度。结果丹奥和葛根素治疗急性脑梗死的临床显效率及神经功能缺损程度评分明显优于对照组(P<0.01)。治疗组CRP、ET及NO在治疗后与对照组相比均有统计学意义。在治疗后7d、14d与对照组比较CRP、ET及NO均明显改变(P<0.05或P<0.01)。结论丹奥联合葛根素治疗急性脑梗死明显优于单独应用丹奥治疗法。To explore the efficacy of ozagrel and puerarin in treatment of acute cerebral infarction. Methods Sixtynine patients （pts） with cerebral infarction were divided randomly into 2 groups： The treatment group （n = 35） treated with Sodium ozagrel （80 mg a day） and puerarin （500 mga day） for 14 days; I he control group （ n = 34） treated with Sodium ozagrel （80 mga day） for 14 days. Plasma C - reactive protein （CRP）, endothelin （ET） and nitric oxide （NO） levels, ET and NO were detected before the treatment and at 7th and 14th day. Results The effect of ozagrel with puerarin was better in treatment group than that in the control group（P〈0.01 ）. The levels of plasma ET and CRP decreased significantly at 7th day in treatment group （P 〈 0.01 ）. The levels of plasma ET and CRP decreased significantly at 14th day, NO level increased significantly at 14th day（ P 〈 0.01 ） in control group. There was significant difference in CRP, ET and NO between treatment group and congrol group after 7 days. Conclusions The results indicated that the efficacy of ozagrel with puerarin in treatment of acute cerebral infarction was better than that used alone.

关 键 词：脑梗死 葛根素 丹奥 C-反应蛋白 内皮素 一氧化氮 

分 类 号：R743.33[医药卫生—神经病学与精神病学]