养阴减毒汤防治急性放射性食管炎的疗效观察  

Clinical study on the effect of Yangyinjiandu decoction on acute raditation esophagitis

作　　者：方平[1] 王发渭[1] 崔书祥[1] 焦顺昌[1] 

机构地区：[1]中国人民解放军总医院肿瘤科,北京100853

出　　处：《中华放射肿瘤学杂志》2005年第5期404-406,共3页Chinese Journal of Radiation Oncology

摘　　要：目的观察中药养阴减毒汤对急性放射性食管炎的防治效果。方法60例确诊为肺癌或纵隔肿瘤并采用放疗的患者随机分为研究组与对照组。研究组自放疗始口服养阴减毒汤剂(1剂/d,200 ml/次,2次/d)至放疗结束。对照组自放疗始至结束口服维生素C片(100 mg/次,3次/d),放疗第5天始强地松片(5 mg/次,3次/d)、阿莫西林胶囊(500 mg/次,3次/d)连服1周,放疗3周后再重复用药1周。两组病例均采用电子直线加速器高能X线常规分割外照射,照射野包括食管在内,放疗总剂量≥40 Gy,食管照射长度≥10 cm。结果研究组急性放射性食管炎的发生时间为放疗后(14.86±0.34)d,较对照组(13.55±0.26)d延迟(P<0.01),发生急性放射性食管炎分级为2、3级的病例分别为5、0例,与对照组的16、6例比较差异有统计学意义(P<0.05)。养阴减毒汤剂的总有效率为95.2%,显效率为12.0%,均高于对照组(P值均<0.05)。结论养阴减毒汤能推迟放射性食管炎的发病时间,减少发病率,减轻症状,对急性放射性食管炎有一定的防治作用。Objective To investigate the effect of Yangyinjiandu decoction for acute radiation esophagitis, Methods Lung cancer and mediastinal tumor treated by radiotherapy（ portals including oesophagus to a radical tumoricidal dose≥40 Gy, with≥10 cm oesophagus include in radiotherapy）. Patients were randomly divided according to the time of acceptance into the treatment group and the control group. All parameters of the two groups were basically similar and comparable. The treatment group was given Yangyinjiandu decoction （one dose daily, water decoction, 200 ml, twice a day） taken in the morning and in the evening before the end of radiotherapy. The control group was given oral vitamin C tablet 100 mg once a day before the end of radiotherapy. Five days after radiotherapy, the control group took oral prednisone 5 mg three times a day and amoxicillin 5g three times a day. All the above medicines were continued for 7 days. Results The commencement of complication was 14.86 ± 0.34 days in the treatment group and 13.55 ± 0.26 days in the control group（ P 〈 0.01 ）. The degree of complication was significantly less mild in the treated group than the control group. Complication of acute group Ⅱ and Ⅲ radiation esophagitis rates were 5 and 0 in the treatment group and 16 and 6 in the control group（ P 〈 0.05 ）. The overall effective rate were 95.2% and marked effective rate 12.0% of the treated group but were statistically higher than those of the control group. Conclusions Yangyinjiandu decoction is effective and better reliable in treating acute radiation esophagitis.

关 键 词：食管炎 放射性 辐射防护剂 治疗结果 急性放射性食管炎 养阴减毒汤 防治作用 疗效观察 电子直线加速器 阿莫西林胶囊 

分 类 号：R734[医药卫生—肿瘤]