肾癌三维彩色血管定量与病理组织学分级及微血管密度的相关研究  

Correlation between Three-dimensional Color Power Angiographic Quantification and Histopathological Grade,Microvessel Density in Renal Cell Carcinoma

作　　者：麻继红[1] 赵玉珍[2] 王小玲[3] 纪晓惠[2] 叶卫华[4] 

机构地区：[1]河北医科大学中医院,石家庄市050011 [2]河北医科大学第四医院超声科 [3]河北医科大学第四医院病理科 [4]河北医科大学

出　　处：《中国超声医学杂志》2005年第9期687-690,共4页Chinese Journal of Ultrasound in Medicine

基　　金：河北省卫生厅科技攻关项目(No.01045)

摘　　要：目的探讨肾癌三维彩色血管定量指标血管指数(vascularity index ,VI)与术后病理组织学分级、微血管密度(microsvessel density,MVD)的相关性.方法应用三维彩色血管能量成像技术(three-dimensional color power angiography,3D-CPA)术前检查50例肾癌患者,计测VI值;术后对肿瘤组织标本HE染色,进行病理组织学分级,用抗CD105单克隆抗体及抗CD34单克隆抗体行免疫组织化学染色,计测MVD值,对结果进行统计学分析.结果 50例肾癌患者VI与MVD呈正相关(r=0.554,P＜0.05),术后病理组织学分级Ⅰ～Ⅲ级,各病理组织学分级之间VI与MVD比较,差异有统计学意义(P＜0.05),箱式图显示肾癌病理组织学分级与VI、MVD呈相关趋势,随病理组织学分级的增高,VI、MVD亦增高.结论肾癌3D-CPA定量指标VI与肿瘤病理MVD相关密切,VI能在术前客观显示肾癌不同病理组织学分级的血管分布情况,可作为判断肾癌预后的定量指标.Objective To explore the correlation between an quantitative index-vascularity index （VI） generated from three-dimensional color power angiography and histopathological grades, the microvessel density （MVD） in renal cell carcinoma （RCC） . Methods Fifty RCCs were examined with three-dimensional color power angiography and the VI was calculated preoperatively. After operation all the slices of tumor tissue specimens were stained with HE and graded in histopathology. Immunohistochemistry was done with anti-CD105 and anti-CD34 monoclonal antibody and MVD was calculated respectively. Then the VI, MVD and histopathological grades were analyzed statistically. Results VI and MVD showed positive correlation （r=0. 487, P〈0. 05） in the 50 RCCs. After operation histopathology were graded Ⅰ～Ⅱ . The MVD and VI in different histopathological grades were different significantly （P〈0.05） . There were relative tendency between VI, MVD and histopathological grades displayed by statistical box plot. With the histopathological grades of RCC was higher, the VI and MVD were higher. Conclusions There were significant correlation between VI and pathological MVD. VI could show the vascular distributions of RCC in different histopathological grades objectively, and evaluate RCC＇s prognosis preoperatively.

关 键 词：肾癌 三维彩色血管定量 病理组织学分级 微血管密度 血管分布 疾病预后 

分 类 号：R737.11[医药卫生—肿瘤]