口腔白斑及鳞状细胞癌中c-Myc及hTERT蛋白表达的研究  

Study on the Expression of c-Myc and hTERT in Oral Leukoplakia and Oral Squamous Cell Carcinoma

作　　者：秦红霞[1] 马丽华[1] 韩冰[2] 石爱梅[2] 

机构地区：[1]郑州大学口腔医学院,河南郑州450052 [2]郑州大学第一附属医院口腔科,河南郑州450052

出　　处：《河南科技大学学报（医学版）》2005年第3期161-163,共3页Journal of Henan University of Science & Technology:Medical Science

基　　金：郑州市科委科研基金资助[2004]6号04BA60ABYD15

摘　　要：目的研究c-Myc和hTERT蛋白在口腔白斑和鳞状细胞癌中的表达及其与二者发生发展的关系。方法采用免疫组化方法检测口腔白斑48例、鳞状细胞癌41例和10例正常口腔粘膜组织中c-Myc和hTERT蛋白的表达,并进行统计学处理分析。结果在正常口腔粘膜组、单纯增生性白斑组、异常增生性白斑组和OSCC组c-Myc蛋白表达的阳性率分别为0(0/10)、21.43%(3/14)、52.94%(18/34)、75.61%(31/41),组间差异有统计学意义(P<0.05);在正常口腔粘膜组、单纯增生性白斑组、异常增生性白斑组和OSCC组hTERT蛋白表达的阳性率分别为0(0/10)、7.14%(1/14)、32.36%(11/34)、58.54%(24/41),组间差异有统计学意义(P<0.05)。结论c-Myc蛋白、hTERT蛋白的表达与细胞增殖及肿瘤的发生密切相关,可能是检测OLK恶变潜能的指标。Objective To investigate the expression of c-Myc and hTERT and their relation between the development of OLK and OSCC. Methods Immurtohistochemical staining technique was used to detect expression of c-Myc and hTERT protein in 48 cases of OLK, 41 cases of OSCC and 10 cases of normal oral mucosa. All data were analyzed statistically. Results The expression rates of c-Myc protein in normal control group; simple hyperplasia OLK, dysplasia OLK and OSCC were 0（0/10）, 21.43 % （3/14）, 52.94% （18/34） and 75.61% （31/41） respectively, showed a significant difference among them （P〈0.05）; the expression rates of hTERT protein in normal control group, simple hyperplasia OLK, dysplasia OLK and OSCC were 0（0/10）, 7.14% （1/14）, 32.36% （11/34） and 58.54% （24/41） respectively, showed significant difference among them （ P〈0.05）. Conclusion The expression of c-Myc and hTERT protein may be closely related to cell proliferation, differentiation and carcinogenesis.They may be useful index for evaluating the malignant potential of OLK.

关 键 词：口腔白斑 口腔鳞状细胞癌 端粒酶催化亚单位 C-MYC 

分 类 号：R739.85[医药卫生—肿瘤]