缺血性脑卒中与肺炎衣原体感染的关系  

RELATIONSHIP BETWEEN CHLAMYDIA INFECTION OF PNEUMONIA AND ISCHEMIC STROKE

作　　者：邓英太[1] 曾莲意[1] 黄宗青[1] 李爱东[1] 张国良[2] 

机构地区：[1]广东医学院附属深圳福田医院神经内科,深圳518033 [2]广东医学院附属深圳心血管疾病研究所,深圳518033

出　　处：《海南医学院学报》2005年第4期269-271,共3页Journal of Hainan Medical University

基　　金：深圳市卫生科技计划项目(NO.200405201)

摘　　要：目的:探讨肺炎衣原体感染与缺血性脑卒中的关系。方法:采用间接微量免疫荧光法测定78例缺血性脑梗死患者血清肺炎衣原体特异性抗体IgG、IgM(Cpn-IgG、Cpn-IgM)的滴度,并与75例健康对照者比较。结果:脑梗死组和对照组的Cpn-IgG抗体滴度分别为(94.6±2.67)和(26.7±2.85),有极显著性差异(P<0.01),病例组与对照组的总感染率分别为96.2%和69.3%,既往感染率分别为83.4%和66.7%,急性感染率分别为12.8%和2.7%,两组总感染率的比较有极显著性差异(P<0.01),两组既往感染率及急性感染率的比较有显著性差异(P<0.05)。结论:缺血性脑卒中与肺炎衣原体感染有密切关系。Objective： To study the relationship between the chronic infection with chlamydia pneumonia and ischemic stroke. Methods： Chlamydia pneumoniae-specific IgG and IgM antibodies in serum were measured by microimmunofluorescence lest from 78 patients with ischemic stroke and 75 health people as the control. Results： The antibody titers of CPn-IgG were（94.6±2.67） and （26.7±2.85） in both patient and control group respectively （P〈0.01）. The total infectious rates were 96.2 % and 69.3 % respectively for both groups （P〈0.01）. The previous infectious rates and acute infectious rates were 83.4% and 12.8 % in patient group, 66.7 % and 2.7 % in control group respectively （P〈0.05） . The frequency of total infection , previous infection and acute infection were significantly higher in patients with ischemic stroke than control. Geometric mean IgG liter was significantly higher in patients with ischemic stroke compared with the controls. Conclusion： Chronic chlamydia pneumoniae infection may be a risk factor of ischemic stroke.

关 键 词：脑梗死 脑缺血 肺炎 衣原体 血清抗体 间接微量免疫荧光法 

分 类 号：R743[医药卫生—神经病学与精神病学]