乳腺囊内乳头状癌1例报道及文献复习  

Intracystic papillary carcinoma of the breast:Report a case and review of the literature

作　　者：喻朝霞[1] 戴瑜珍 胡小安[1] 张润[1] 

机构地区：[1]安徽省安庆市第一人民医院病理科,246003

出　　处：《蚌埠医学院学报》2005年第5期421-423,F0004,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨乳腺囊内乳头状癌(intracystic papillary carcinoma,IPC)的临床病理特征及诊断和鉴别诊断。方法:分析1例乳腺囊内乳头状癌临床和病理改变,结合文献对该肿瘤的临床表现、病理形态学特征及诊断和鉴别诊断要点进行讨论。结果:囊内乳头状癌大体呈结节状,切面呈囊性,囊内壁见乳头状突起,灰白色。镜下肿瘤由粗大的乳头构成,乳头有纤维脉管轴心,癌细胞单层、复层排列,细胞为高柱状、梭形,未见核分裂象。免疫表型:癌细胞CK7(+),EMA(+),SMA(-),actin(-),CK(34βE12)(-),S-100蛋白(-),p63(-),ER(-),PR(-),c-erbB-2(-),E-cadherin(E-cad)(+),p53(+),Ki-67(+)。结论:IPC是乳腺十分少见的上皮性肿瘤,由于组织学形态多样,常易引起病理误诊。鉴别诊断必须首先排除乳腺乳头状瘤、肌上皮瘤、乳头状转移性肿瘤等。Objective：To study the pathologic characteristics and differential diagnosis of intracystic papillary carcinoma（IPC） of the breast. Methods：The clinical and pathological findings of one case of IPC of the breast were reported and the differential diagnosis was discnssed with review of the literature. Results：The tumor was a gross and irregular nodule,gray-white color and intracystic on cut surface. The papillary was seen inside the capsule wall microscopically. The tumor was constituted of big papilla and the papilla contained fibrovascular stalks. One or more layers of malignant cells laid alignment, the cells were of high columnar form and shuttle form, and no mitotic figures detected. Immunohistochemically, the tumor cells were positive for CK7, EMA, E-cad,p53 and Ki-67, but negative for SMA, S- 100 protein, actin, ER, PR, c-erbB-2, p63, CK （34βE12） and CEA. Conclusions： IPC is a rare epithelial tumor. Its varied histology and morphology often lead to misdiagnosis. It must be distinguished from papilloma, myoepithelial tumor and various metastastic papillary carcinomas in making a diagnosis.

关 键 词：乳腺肿瘤 囊内乳头状癌 病理学 临床 诊断 鉴别 

分 类 号：R737.9[医药卫生—肿瘤]