持续性肾脏替代疗法对重症急性胰腺炎的疗效分析——国内159例复习  

Analysis of therapeutic outcome of continuous renal replacement therapy for severe acute pancreatitis: review of 159 cases in China.

作　　者：张美华[1] 贾林[1] 秦曙光[2] 

机构地区：[1]广州市第一人民医院消化内科,广东510180 [2]广州市第一人民医院 肾内科,广东510180

出　　处：《胰腺病学》2005年第3期150-153,共4页Chinese JOurnal of Pancreatology

摘　　要：目的评价持续性肾脏替代治疗对重症急性胰腺炎的疗效。方法检索国内1994至2004 年间文献,共获得持续性肾脏替代治疗重症急性胰腺炎155例,联合我院4例共159例,非持续性肾脏替代治疗对照组57例,进行回顾性分析。结果重症急性胰腺炎通过个体化的综合治疗联合持续性肾脏替代治疗,患者临床症状、体征、血生化指标、APACHE Ⅱ评分均显著改善,细胞因子和内毒素水平明显下降,存活率提高至76.7%,死亡率降至23.3%;对照组存活率为59.6%,死亡率为40.4%。结论持续性肾脏替代疗法对重症急性胰腺炎具有肯定的疗效,且早期足疗程治疗效果更佳。Objective To evaluate therapeutic outcomes of continuous renal replacement therapy （CRRT） for severe acute pancreatitis. Methods A total of 155 patients with severe acute pacreatitis who were treated with CRRT between 1994 and 2004, including 155 cases reported in the domestic literature and 4 treated in our hospital, were reviewed retrospectively. Another 57 SAP patients who received non CRRT treatment were used as control. Results Through individualized treatment in combination with CRRT. significant improvement was seen in the clinical symptoms, serum biochemical indexes and APACHE Ⅱ scores; cytokine and endotoxin levels were greatly decreased; the curative rate rose to 76.7% versus 59. 6% of the control group, and the death rate decreased to 23.3% versus 40. 4% of the control group, Conclusions The therapeutic outcome of continuous renal replacement therapy for severe acute pancreatitis is positive and definite. Early use and a sufficient course of continuous renal replacement therapy would provide a better outcome.

关 键 词：胰腺炎、急性坏死性 肾替代疗法 治疗 持续性肾脏替代疗法 重症急性胰腺炎 疗效分析 持续性肾脏替代治疗 国内 APACHEⅡ评分 复习 

分 类 号：R576[医药卫生—消化系统]