白细胞介素-1受体拮抗剂对内毒素性前葡萄膜炎治疗作用的实验研究  

A study of the effects of an interleukin-1 receptor antagonist on endotoxin-indueed uveitis of rats

作　　者：孙旭光[1] 张文华[1] 

机构地区：[1]北京市眼科研究所,100005

出　　处：《眼科》1996年第2期110-111,共2页Ophthalmology in China

摘　　要：实验利用革兰氏阴性细菌的脂多糖(内毒素),建立大鼠前葡萄膜炎模型。通过分析房水蛋白含量,房水细胞计数及病理学变化,观察了白细胞介素-1受体拮抗剂的抗炎作用。结果表明,白细胞介素-1受体拮抗剂可显著减少房水蛋白含量和细胞数,并明显抑制多形核白细胞的浸润。由此认为白细胞介素-1受体拮抗剂具有抑制细菌内毒素性前葡萄膜炎的作用。The injection of lipopolysaccharides (Endoxin) derived from gram-negatlve bacteria into the foot pad of rat produced the acute anterior uveitis. Interleukin-1 has been implicated in such inflammation, In this study, we evaluated the anti-inflammatory effects of a cloned recombinant interleukin-1 receptor antagonist (IL-lra) by measuring the cell count, protein content in the aqueous humor and examining histopathological features. The results shows that IL-lra can significantly reduce the cell count and protein leakage in the aqueous humor and decrease the polymorphonuclear leukocyte infiltration in the eye. It is suggested that IL-lra be effective in the suppression of endotoxin-induced uveitis.

关 键 词：白细胞介素-1 受体拮抗剂 内毒素 葡萄膜炎 

分 类 号：R773.905[医药卫生—眼科] R979.5[医药卫生—临床医学]