自发性高血压大鼠血管平滑肌CaN与心肌ATP酶活性变化  

Active Change of CaN in Artery Smooth Muscle Cell and Na^+-K^+-ATPase in Myocardic with Spontaneous Hypertension

作　　者：刘艳明[1] 王雪芳[2] 马建伟[2] 温晓竞[2] 

机构地区：[1]中国人民解放军251医院心内科,河北张家口075000 [2]河北北方学院生理教研室,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2005年第4期11-13,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:研究自发性高血压大鼠不同血管平滑肌钙调神经磷酸酶(CaN)的活性与心肌ATP酶活性变化。方法:应用酶活性测定12周自发性高血压大鼠(SHR)和Wistar大鼠的胸主动脉(A)、肠系膜动脉(MA)、尾动脉(CA)血管平滑肌CaN及其心肌Na+-K+-ATPase的活性。结果:SHR大鼠不同血管CaN的活性与对照组相应的变化无显著差异,而其在CA中的活性明显低于在A的活性,在阻力血管MA中活性却无明显降低;Na+-K+-ATPase的活性与其对照组相应的变化有显著差异(P<0·01);SHR大鼠血压和左心室肥厚指数增加(P<0·05)。结论:SHR大鼠血压和左心室肥厚指数增加,SHR大鼠血压与其对照组相比不同血管平滑肌CaN的活性变化无显著差异,Na+-K+-ATPase的活性发生下降。Objective：To study the active change of Ca^2＋/CAM-Protein phosphatase（CaN） in different artery smooth muscle cell and the activity of Na^＋- K^＋ - ATPase in myoeardie with Spontaneous Hypertension. Methods： By the enzymologic measuring method we compared the change of the CaN and Na^＋ - K^＋ - ATPase from wister rats and SHR. Results： There are not significant differences between the SHR group and the wister group in the activities of CaN in different artery smooth muscle cell , but the activities of CaN in CA decreased significantly,and the activities of CaN in MA didn＇t change; the activities of Na^＋ -K^＋ -ATPase myocardia for SHR was decreased（P〈0.01） and LVH/BP for SHR were increased as well （P〈0.05）. Conclusion： There are not significant differences between the SHR group and the wister group in the activity of CaN in different artery smooth muscle cell and Na^＋ -K^＋ -ATPase in myocardia with Spontaneous Hypertension were decreased and LVH/BP for SHR were increased.

关 键 词：自发性高血压 CAN NA^+-K^+-ATPASE 左心室肥厚 

分 类 号：R-332[医药卫生]